NCT01272674CompletedPhase 1
Adiponectin Promotes the Migration of Circulating Progenitor Cells Through p38-mediated Induction of the CXCR4 Receptor
University of Leipzig2 sites in 1 country20 target enrollmentStarted: January 1, 2011Last updated:
Conditions
Trial Snapshot
- Phase
- Phase 1
- Status
- Completed
- Sponsor
- Enrollment
- 20
- Locations
- 2
- Primary Endpoint
- migratory capacity of endothelial progenitor cells towards an SDF-1 gradient
Study Overview
Brief Summary
Adiponectin and exercise training contribute to the maintenance of a normal vascular tone by influencing vascular NO bioavailability and concentration and function of endothelial progenitor cells. The molecular mechanisms are only partially understood. Therefore, aim of the present study is to elucidate the effects of Adiponectin on endothelial progenitor cell migration and the underlying signaling pathways. Furthermore, the impact of exercise training on adiponectin-mediated endothelial progenitor cell migration will be investigated.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 75 Years (Adult, Older Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •≤ 75 years of age
- •stable coronary artery disease
- •preserved left ventricular function
- •physical work capacity of ≥ 50
- •successful elective percutaneous coronary intervention at study begin
Exclusion Criteria
- •diabetes mellitus
- •hypercholesterolemia
- •untreated hypertension
- •myocardial infarction within the last 4 weeks
- •significant stenosis of the left main coronary artery
Outcomes
Primary Outcomes
migratory capacity of endothelial progenitor cells towards an SDF-1 gradient
Time Frame: 4 weeks
Secondary Outcomes
No secondary outcomes reported
Investigators
Prof. Dr. med. A. Linke
Co-investigator
University of Leipzig
Study Sites (2)
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