Adiponectin and Circulating Progenitor Cells (CPC) Function
Phase 1
Completed
- Conditions
- Coronary Artery Disease
- Interventions
- Other: exercise training
- Registration Number
- NCT01272674
- Lead Sponsor
- University of Leipzig
- Brief Summary
Adiponectin and exercise training contribute to the maintenance of a normal vascular tone by influencing vascular NO bioavailability and concentration and function of endothelial progenitor cells. The molecular mechanisms are only partially understood. Therefore, aim of the present study is to elucidate the effects of Adiponectin on endothelial progenitor cell migration and the underlying signaling pathways. Furthermore, the impact of exercise training on adiponectin-mediated endothelial progenitor cell migration will be investigated.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 20
Inclusion Criteria
- ≤ 75 years of age
- stable coronary artery disease
- preserved left ventricular function
- physical work capacity of ≥ 50
- successful elective percutaneous coronary intervention at study begin
Exclusion Criteria
- diabetes mellitus
- hypercholesterolemia
- untreated hypertension
- smoking
- myocardial infarction within the last 4 weeks
- significant stenosis of the left main coronary artery
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description exercise training exercise training 4 weeks of supervised physical exercise training
- Primary Outcome Measures
Name Time Method migratory capacity of endothelial progenitor cells towards an SDF-1 gradient 4 weeks
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Leipzig, Heart Center
🇩🇪Leipzig, Germany