Correlation Between Various Adipokines and Vascular Inflammation Measured by Positron Emission Tomography (PET) With 18F-fluoro-deoxyglucose (FDG) (18FDG-PET)

Completed

• Conditions: Atherosclerosis
• Interventions: Other: Cross sectional study

• Registration Number: NCT01150006
• Lead Sponsor: Korea University

Brief Summary

The inflammatory state and composition of atherosclerotic plaques are considered the main contributing factors responsible for acute cardiovascular events, rather than the degree of stenosis. Recently, positron emission tomography (PET) with 18F-fluoro-deoxyglucose (FDG) has been suggested as a promising novel imaging technique to identify the inflammatory state of atherosclerotic plaque. Recently, a few clinical studies showed that circulating A-FABP level had a close relation with the development of atherosclerosis in human. Therefore, in the present study, the investigators examined the relationship between circulating A-FABP and vascular inflammation of carotid arteries measured using FDG-PET in healthy male subjects.

Detailed Description

Not available

Study Timeline

• Status Verified: 2010-04
• Study Start: 2010-04
• Primary Completion: 2010-06
• Study Completion: 2010-06
• Study First Submitted: 2010-06-09
• Study First Submitted QC: 2010-06-23
• Study First Posted: 2010-06-24
• Last Update Submitted: 2010-06-28
• Last Update Posted: 2010-06-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 90

Inclusion Criteria

• Healthy male volunteers for visiting routine medical check in our clinic

Exclusion Criteria

• History of cardiovascular disease (myocardial infarction, unstable angina,stroke, or cardiovascular revascularization)
• Diabetes
• Hypertension
• Malignancy
• Severe renal or hepatic disease
• Subjects taking medications that might affect inflammation such as NSIAD and statin

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Healthy male participants	Cross sectional study	-

Primary Outcome Measures

Name	Time	Method
Vascular inflammation in carotid arterial wall, represented as the target-to-background ratio (TBR), using FDG-PET	12 weeks

Secondary Outcome Measures

Name	Time	Method
Circulating serum leptin levels	12weeks
Circulating serum adiponectin levels	12 weeks
Carotid intima-media thickness levels measured using ultrasonography	12 weeks
Circulating serum A-FABP levels	12 weeks

Trial Locations

Locations (1)

Hye Jin Yoo; 🇰🇷 Seoul, Korea, Republic of