Correlation Between NAFLD, Epicardial Adipose Tissue and Vascular Inflammation Measured by Positron Emission Tomography (PET) With 18F-fluoro-deoxyglucose (FDG)

Completed

• Conditions: Atherosclerosis; Non-alcoholic Fatty Liver Disease

• Registration Number: NCT01958411
• Lead Sponsor: Korea University

Brief Summary

* Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.

* Non-alcoholic fatty liver disease (NAFLD) is closely associated with many cardiometabolic risk factors. NAFLD can be detected by measuring liver fat accumulation using computed tomography (CT).

* Also epicardial adipose tissue (EAT) volume as determined by computed tomography (CT) is an independent marker of cardiovascular events in the general population.

* Therefore, the purpose of this investigators study is to compare the NAFLD severity and EAT volume with FDG uptake measured by PET/CT.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-12
• Primary Completion: 2011-03
• Status Verified: 2013-10
• Study First Submitted: 2013-10-07
• Study First Submitted QC: 2013-10-07
• Last Update Submitted: 2013-10-07
• Study First Posted: 2013-10-09
• Last Update Posted: 2013-10-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 340

Inclusion Criteria

• Healthy patients for visiting routine medical check in our clinic

Exclusion Criteria

• History of cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization)
• Diabetes
• Stage 2 hypertension (resting blood pressure, ≥ 160/100 mmHg)
• Malignancy
• Severe renal or hepatic disease
• Subjects taking medications that might affect inflammation such as nonsteroidal antiinflammatory drug and statin

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correlation between vascular inflammatory status measured by 18FDG PET and NAFLD measured by un-enhanced CT	12 weeks
Correlation between vascular inflammatory status measured by 18FDG PET and epicardial adipose tissue measured by CT	12 weeks

Secondary Outcome Measures

Name	Time	Method
The relationship of NAFLD with carotid intima media thickness	12 weeks
The relationship of epicardial adipose tissue volume with carotid intima media thickness	12 weeks

Trial Locations

Locations (1)

Korea University Guro Hospital; 🇰🇷 Seoul, Korea, Republic of