Correlation Between Various Inflammatory Markers and Vascular Inflammation Measured by 18FDG-PET
Completed
- Conditions
- Atherosclerosis
- Interventions
- Other: Cross section study
- Registration Number
- NCT01022684
- Lead Sponsor
- Korea University
- Brief Summary
Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. Various inflammatory markers such as LpPLA2,MCP-2 and hsCRP are well-known prognostic factors for the cardiovascular event.
18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.Therefore, the purpose of the study is to demonstrate the correlation between various inflammatory markers and vascular inflammation detected by 18FDG-PET.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 150
Inclusion Criteria
- Healthy patients for visiting routine medical check in our clinic
Exclusion Criteria
- History of cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization)
- Diabetes
- Stage 2 hypertension (resting blood pressure, ≥160/100 mmHg)
- Malignancy
- Severe renal or hepatic disease
- Subjects taking medications that might affect inflammation such as NSIAD and statin
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Healthy patients Cross section study -
- Primary Outcome Measures
Name Time Method Correlation between various inflammatory markers including LpPLA2,MCP-1 and hsCRP and vascular inflammation analyzed by 18FDG-PET 12 weeks
- Secondary Outcome Measures
Name Time Method Correlation between various inflammatory markers and atherosclerosis measured by carotid intima media thickness 12 weeks
Trial Locations
- Locations (1)
Hye Jin Yoo
🇰🇷Seoul, Korea, Republic of