Acute effect of a single dose of N-acetylcysteine (NAC) on prooxidant/antioxidant balance, intestinal barrier permeability and markers of skeletal muscle damage in physically active men.

Not Applicable

• Conditions: Oxidative stress; Inflammation; Muscle damage; Inflammatory and Immune System - Normal development and function of the immune system; Blood - Normal development and function of platelets and erythrocytes; Oral and Gastrointestinal - Normal oral and gastrointestinal development and function

• Registration Number: ACTRN12624000546550
• Lead Sponsor: niversity of Physical Education in Katowice

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-04-30
• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: Male
• Target Recruitment: 40

Inclusion Criteria

Selection of individuals for the study will be conditional on meeting the following criteria:
- absence of symptoms suggestive of blood clotting disorders,
- absence of congenital and acquired heart defects confirmed by echocardiography performed at the Academic Medical Centre prior to the study,
- voluntary consent for the examination,
- having a permission to take part in the examination issued by a doctor belonging to the research team,
- experiance of sports training for at least 3 years,
- men of full age, physically active,
- not taking antibiotics, nitroglycerin, nitrates or cough suppressants in the period preceding (at least 2 months) and during the study,
- no sensitivity to any ingredient of the preparation, no diseases, i.e. acute asthma attack, gastric ulcer and/or duodenal ulcer,
- subjects not taking antioxidant supplements and/or anti-inflammatory drugs in the period preceding (at least 2 months) the study and during their implementation.
- no previous injuries in the musculoskeletal system involving the lower limbs.

Exclusion Criteria

None

Study & Design

• Study Type: Interventional
• Study Design: Not specified