EFFECT OF ACUTE ADMINISTRATION OF N-ACETYLCYSTEINE ON BLOOD PRESSURE OF PULMONARY ARTERIAL IN PRIMARY PULMONARY HYPERTENSION. - ND

• Conditions: PRIMARY PULMONARY HYPERTENSION; MedDRA version: 9.1Level: LLTClassification code 10036727

• Registration Number: EUCTR2009-014534-15-IT
• Lead Sponsor: AZIENDA SANITARIA OSPEDALIERA S. GIOVANNI BATTISTA DI TORINO

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2009-09-15
• Last Update Posted: 3 April 2012

Recruitment & Eligibility

• Status: Authorised-recruitment may be ongoing or finished
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

- PRIMARY PULMONARY HYPERTENSION EVALUATED WITH RIGHT CARDIAC CATHETERISM
- NEGATIVE RESULT TO VASODILATOR TEST IN RIGHT CARDIAC CATHETERISM
- INFORMED WRIGHT CONSENT
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

- CONTROINDICATIONS TO PULMANRY CATHETERISM
- TREATMENT WITH N-ACETYLCYSTEINE DURING THE 6 MONTHS BEFORE THE STUDY
- HIPERSENSITIVITY TO N-ACETYLCYSTEINE
- ABSENCE OF INFORMED WRIGHT CONSENT

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Secondary Objective: NON APPLICABILE;Primary end point(s): EVALUATE THE EFFECT OF THE ANTIOXIDANT THIOLIC COMPOUND N-ACETYLCYSTEINE ON PULMONARY VASODILATION IN PRESENCE OF NITRIC OXIDE ADMINISTERED BY INHALATION IN PATIENTS WITH PRIMARY PULMONARY HYPERTENSION;Main Objective: EVALUATE THE EFFECT OF THE ANTIOXIDANT THIOLIC COMPOUND N-ACETYLCYSTEINE ON PULMONARY VASODILATION IN PRESENCE OF NITRIC OXIDE ADMINISTERED BY INHALATION IN PATIENTS WITH PRIMARY PULMONARY HYPERTENSIO