Fractal Analysis of the Pulmonary Arterial Tree in Pulmonary Hypertension

Completed

• Conditions: Pulmonary Hypertension
• Interventions: Other: No Intervention

• Registration Number: NCT01135706
• Lead Sponsor: Ohio State University

Brief Summary

The investigators propose to confirm that normotensive and hypertensive pulmonary arteries are fractal, as well as define if the FD correlates to disease severity when compared to available data such as six-minute walk and right heart catheterization measurements.

Detailed Description

Pulmonary hypertension (PH) is an insidious disorder that can occur in isolation or as a result of various other pulmonary and systemic conditions. If left untreated PH may progress to right heart failure and death. Numerous tests are suggestive but not diagnostic of PH including cardiac echo, pulmonary function testing and chest x-ray. Definitive diagnosis requires right heart catheterization that is invasive, costly and time consuming. The fractal dimension (FD) is an index of the space-filling properties of an object so that the closer the dimension is to the topological dimension in which the object is embedded, the greater the space filling properties. No investigations have been performed to analyze the fractal dimension of pulmonary arteries in patients with PH. We propose to confirm that normotensive and hypertensive pulmonary arteries are fractal, as well as define if the FD correlates to disease severity when compared to available data such as six-minute walk and right heart catheterization measurements.

Study Timeline

• Study Start: 2010-04
• Study First Submitted: 2010-05-20
• Study First Submitted QC: 2010-06-02
• Study First Posted: 2010-06-03
• Primary Completion: 2012-02
• Study Completion: 2012-02
• Status Verified: 2012-10
• Last Update Submitted: 2012-10-31
• Last Update Posted: 2012-11-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 6

Inclusion Criteria

• Patients having a right heart catheterization and CT pulmonary angiogram

Exclusion Criteria

• None

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Pulmonary Hypertension	No Intervention	Patients having a right heart catheterization and CT pulmonary angiogram with a diagnosis of Pulmonary Hypertension
Non Pulmonary Hypertension	No Intervention	Patients having a right heart catheterization and CT pulmonary angiogram without a diagnosis of Pulmonary Hypertension.

Primary Outcome Measures

Name	Time	Method
FD of the pulmonary artery in patients with PH will be lower when compared to patients without PH.	24 Months

Secondary Outcome Measures

Name	Time	Method
FD will correlate with the degree of PH as quantified by the MPAP obtained during RHC.	24 Months
FD will correlate with the functional capacity of the PH patients as quantified by distance during six-minute walk and NYHA functional class.	24 Months

Trial Locations

Locations (1)

The Ohio State University Medical Center; 🇺🇸 Columbus, Ohio, United States