The value of MRI diagnostics in haemophilic arthropathy: a pilot study

Completed

Conditions: FVIII/FIX deficiency
10064477
haemophilia
10023213

Registration Number: NL-OMON37969

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 56

Inclusion Criteria

• Haemophilia A or B
• Severe (<1% FVIII/IX activity) (n=20) or moderate haemophilia (1-5% FVIII/IX activity) (n=10).
• 12-26 years of age
• Recent Pettersson scores (within two years of assessment) available
• maximum one knee or ankle with a score above 3 points
• minimal two ankles or knees with a score of 0 points
• entry clinic before age 4
Controls:
• male, 18-26 years of age
• participating in regular sports (1-3x/wk )

Exclusion Criteria

• History of inhibitors
• No access to standard care since birth (e.g. immigration from other
country)
• Last Pettersson score more than 2 years before assessment
• More than one knee or ankle with a Pettersson score above 3 points
• Less than two knees or ankles with a Pettersson score of 0 points
• Extensive bleeding in knees or ankles 2/3 weeks before assessment
Controls
• contraindication for MRI assessment
• knee/ankle injuries within 8 weeks prior to MRI
* sports participation less than once weekly or more than 3 times weekly

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Determinant: MRI findings according to the Lundin additive Score.<br /><br>Outcome parameters:<br /><br>Diagnostic study: HJHS score (T=0)<br /><br>Pettersson score (T=0)<br /><br>Prognostic study: delta HJHS score (T=2.5 and T=5 years)<br /><br>delta Pettersson score (T=5 years)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The association of MRI with delta HJHS after 2.5 and 5 years' interval will be<br /><br>adjusted for baseline HJHS score, number of joint bleeds during the observation<br /><br>interval, physical activity, and age.<br /><br><br /><br>The association of MRI with delta Pettersson score after 5 years' interval will<br /><br>be adjusted for baseline Pettersson score, number of joint bleeds during the<br /><br>observation interval, physical activity, and bone age.</p><br>