Genetic and protein profiling inpatients with oesophageal cancer.

Recruiting

• Conditions: oesophageal neoplasmsprotein profilinggene expression profilingneoadjuvant treatment

• Registration Number: NL-OMON19982

Brief Summary

/A

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

1. Patients presenting at the NKI-AvL or LUMC for the treatment of oesophageal cancer;

2. Planned gastroduodenoscopy (for diagnosis, feeding tube insertion, dilatation, etc.) or endoscopic ultrasonography (for staging) before the start of therapy;

Exclusion Criteria

1. Any condition that prohibits safe biopsy sampling (e.g. use of anticoagulants);

2. Incapacity or unwillingness to give written informed consent.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The following comparisons will be performed:<br /><br>1. Patients who are diagnosed with metastatic disease within 1 year after diagnosis versus patients without metastatic disease within 1 year after diagnosis;<br /><br>2. Patients in whom the tumour shows partial or complete response to preoperative or definitive chemoradiotherapy versus patients in whom the tumour is unresponsive to this type of treatment.