Normative EndoFlip Data on the Diameter and Distensibility of the Pylorus During Fasting and Postprandially in Healthy Females and Male Adults
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Healthy
- Sponsor
- Mayo Clinic
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- fasting and postprandial pyloric diameter
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
The purpose of this research is to establish the normal range of diameter and distensibility of pylorus and the fasting and postprandial antro-pyloric motility in healthy adults.
Detailed Description
An Endoflip catheter will be placed through the mouth into the stomach in order to measure distal antral contractile activity and pyloric diameter and distensibility during fasting and after the ingestion of a standard meal
Investigators
Michael Camilleri, MD
Principal Investigator
Mayo Clinic
Eligibility Criteria
Inclusion Criteria
- •Females and males.
- •Between the ages of 18 and 65 years.
- •Body mass index between 18 and 35 kg/m\^2.
Exclusion Criteria
- •Heartburn, regurgitation, or symptoms suggestive of gastroparesis such as nausea, early satiety, postprandial bloating, and upper abdominal pain.
Outcomes
Primary Outcomes
fasting and postprandial pyloric diameter
Time Frame: 1 hour prior to meal and 1 hour following standardized meal
Change in Pyloric diameter will be measured during fasting and postprandial using Endoflip
fasting and postprandial pyloric distensibility index
Time Frame: 1 hour prior to meal and 1 hour following standardized meal
Change in Pyloric distensibility index will be measured during fasting and postprandial using Endoflip
fasting and postprandial distal antral motility index
Time Frame: 1 hour prior to meal and 1 hour following standardized meal
Change in distal antral motility index will be measured during fasting and postprandial using Endoflip