Effect of Exercise Training on Inflammatory Mediators in COPD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- COPD
- Sponsor
- Faculty of Medicine, Sousse
- Enrollment
- 28
- Locations
- 1
- Primary Endpoint
- Enzyme linked immunosorbent assay for serum cytokines levels change
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Chronic obstructive pulmonary disease (COPD) is widely spread all over the world. It is predicted to be the third leading cause of death by 2020[1]. COPD is a common, preventable treatable disease that is characterized by an airflow limitation which is not fully reversable[2].
Detailed Description
Chronic obstructive pulmonary disease (COPD) is widely spread all over the world. It is predicted to be the third leading cause of death by 2020. COPD is a common, preventable treatable disease that is characterized by an airflow limitation which is not fully reversable.Not only the long-term exposition to noxious particles and gases contributes to the development of COPD, but also so many others factors such as genetics and cigarette smoking. It has been shown that cigarettes are harmful and contributed to different extra pulmonary disorders. Indeed, it induced a systemic inflammation that was considered as a key process in the pathogenesis of COPD and triggered the activation of inflammatory cells and an abnormal increase of circulating cytokines such as CRP, interleukin (IL6), IL8, tumor necrosis factor alpha (TNF alpha) and leptin.
Investigators
Acheche Amal
PhD student
Faculty of Medicine, Sousse
Eligibility Criteria
Inclusion Criteria
- •COPD diagnosed by pulmonary function testing
- •Clinically stable
- •Abscence of other obstructive diseases
- •Signed written consent
Exclusion Criteria
- •Neuromuscular diseases -Severe psychiatric, neurologic or musculoskeletal conditions and /or instable--- --
- •cardiovascular diseases.
- •Contre-indications to physical therapy
- •Acute exacerbations a month before the intervention
Outcomes
Primary Outcomes
Enzyme linked immunosorbent assay for serum cytokines levels change
Time Frame: Baseline, 6 months
The interleukines were determined by ELISA assays with commercial kits