Exercise Training and Inflammatory Mediators in COPD

Not Applicable

Completed

• Conditions: COPD
• Interventions: Other: Resistance Training RT; Other: Endurance Training ET

• Registration Number: NCT03853174
• Lead Sponsor: Faculty of Medicine, Sousse

Brief Summary

Chronic obstructive pulmonary disease (COPD) is widely spread all over the world. It is predicted to be the third leading cause of death by 2020\[1\]. COPD is a common, preventable treatable disease that is characterized by an airflow limitation which is not fully reversable\[2\].

Detailed Description

Chronic obstructive pulmonary disease (COPD) is widely spread all over the world. It is predicted to be the third leading cause of death by 2020. COPD is a common, preventable treatable disease that is characterized by an airflow limitation which is not fully reversable.Not only the long-term exposition to noxious particles and gases contributes to the development of COPD, but also so many others factors such as genetics and cigarette smoking. It has been shown that cigarettes are harmful and contributed to different extra pulmonary disorders. Indeed, it induced a systemic inflammation that was considered as a key process in the pathogenesis of COPD and triggered the activation of inflammatory cells and an abnormal increase of circulating cytokines such as CRP, interleukin (IL6), IL8, tumor necrosis factor alpha (TNF alpha) and leptin.

Study Timeline

• Study Start: 2019-01-01
• Study First Submitted: 2019-02-21
• Study First Submitted QC: 2019-02-22
• Study First Posted: 2019-02-25
• Primary Completion: 2019-04-17
• Study Completion: 2019-04-27
• Status Verified: 2019-12
• Last Update Submitted: 2019-12-18
• Last Update Posted: 2019-12-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 28

Inclusion Criteria

• COPD diagnosed by pulmonary function testing
• Clinically stable
• Abscence of other obstructive diseases
• Signed written consent

Exclusion Criteria

• Neuromuscular diseases -Severe psychiatric, neurologic or musculoskeletal conditions and /or instable--- --
• cardiovascular diseases.
• Contre-indications to physical therapy
• Acute exacerbations a month before the intervention

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
RT	Resistance Training RT	Resistance training were prformed. Intensity was gradually increased.
ET	Endurance Training ET	Active Comparator: ET Endurance training were prformed. Intensity was gradually increased.

Primary Outcome Measures

Name	Time	Method
Enzyme linked immunosorbent assay for serum cytokines levels change	Baseline, 6 months	The interleukines were determined by ELISA assays with commercial kits

Trial Locations

Locations (1)

Amal Acheche; 🇹🇳 Sousse, Tunisia