Emotion Regulation in Binge Eating and Purging Among Adolescents

Completed

• Conditions: Binge Eating; Purging (Eating Disorders)
• Interventions: Other: Magnetic resonance imaging

• Registration Number: NCT03429114
• Lead Sponsor: Stanford University

Brief Summary

The study will examine the neural and behavioral correlates of emotion regulation in adolescents engaging in binge eating and/or purging and healthy adolescents. Furthermore, it will look at the influence of executive function on emotion regulation in this population. This study will allow us to gain further understanding of the neural basis of emotion regulation in this age group. Moreover, this study supports the need to develop new treatment approaches based on a better understanding of the brain processes associated with eating disorders.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-10-15
• Study First Submitted: 2018-02-02
• Study First Submitted QC: 2018-02-08
• Study First Posted: 2018-02-12
• Primary Completion: 2022-09-01
• Study Completion: 2022-09-01
• Status Verified: 2022-12
• Last Update Submitted: 2022-12-04
• Last Update Posted: 2022-12-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 47

Inclusion Criteria

• Female
• Ages 14-18
• with or without current binge eating and/or purging behaviors

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Exclusion Criteria

We exclude patients of clinically significant low weight (<85% ideal body weight using CDC norms for height, age, and gender) and those with contraindications for MRI (e.g., orthodontia, metallic implants). Participants also will be without evidence of current or past major neurological (e.g., seizures, psychosis, head trauma) or major sensory deficit.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Binge eating/purging	Magnetic resonance imaging	Adolescents engaging in recurrent binge eating and/or purging behavior.
Healthy comparison	Magnetic resonance imaging	Adolescents who do not have a history of eating disorders

Primary Outcome Measures

Name	Time	Method
Brain activity during cognitive control and emotion response	Baseline	Functional magnetic resonance imaging will be used to measure brain activity during a task where participants engage in cognitive control and respond to emotional stimuli.
Brain activity during emotion conflict	Baseline	Functional magnetic resonance imaging will be used to measure brain activity during a task where participants respond to images of faces with emotional expressions overlaid with an emotion word written in text. We will focus on brain response during this task when emotion face vs word are in conflict.
Brain activity during emotion regulation	Baseline	Functional magnetic resonance imaging will be used to measure brain activity during a task where participants attempt to regulate emotional responses.

Secondary Outcome Measures

Name	Time	Method
Behavioral performance on emotion conflict task	Baseline	Response times will be used as behavioral measure on the emotion conflict task
Behavioral performance on emotion regulation task	Baseline	Emotion ratings will be used as behavioral measure on the emotion regulation task
Behavioral performance on cognitive control and emotion regulation task	Baseline	Emotion ratings will be used as behavioral measure on the cognitive control and emotion regulation task

Trial Locations

Locations (1)

Stanford University, Department of Psychiatry; 🇺🇸 Stanford, California, United States