Neural Correlates of Emotion Regulation and Executive Function in Binge Eating and Purging Among Adolescents
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 47
- 试验地点
- 1
- 主要终点
- Brain activity during cognitive control and emotion response
研究概览
简要总结
The study will examine the neural and behavioral correlates of emotion regulation in adolescents engaging in binge eating and/or purging and healthy adolescents. Furthermore, it will look at the influence of executive function on emotion regulation in this population. This study will allow us to gain further understanding of the neural basis of emotion regulation in this age group. Moreover, this study supports the need to develop new treatment approaches based on a better understanding of the brain processes associated with eating disorders.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 14 Years 至 18 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Ages 14-18
- •with or without current binge eating and/or purging behaviors
排除标准
- •We exclude patients of clinically significant low weight (<85% ideal body weight using CDC norms for height, age, and gender) and those with contraindications for MRI (e.g., orthodontia, metallic implants). Participants also will be without evidence of current or past major neurological (e.g., seizures, psychosis, head trauma) or major sensory deficit.
结局指标
主要结局
Brain activity during cognitive control and emotion response
时间窗: Baseline
Functional magnetic resonance imaging will be used to measure brain activity during a task where participants engage in cognitive control and respond to emotional stimuli.
Brain activity during emotion conflict
时间窗: Baseline
Functional magnetic resonance imaging will be used to measure brain activity during a task where participants respond to images of faces with emotional expressions overlaid with an emotion word written in text. We will focus on brain response during this task when emotion face vs word are in conflict.
Brain activity during emotion regulation
时间窗: Baseline
Functional magnetic resonance imaging will be used to measure brain activity during a task where participants attempt to regulate emotional responses.
次要结局
- Behavioral performance on emotion conflict task(Baseline)
- Behavioral performance on emotion regulation task(Baseline)
- Behavioral performance on cognitive control and emotion regulation task(Baseline)
研究者
Cara Bohon, PhD
Assistant Professo
Stanford University