Neural Correlates of Emotion Regulation and Executive Function in Binge Eating and Purging Among Adolescents
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Binge Eating
- Sponsor
- Stanford University
- Enrollment
- 47
- Locations
- 1
- Primary Endpoint
- Brain activity during cognitive control and emotion response
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
The study will examine the neural and behavioral correlates of emotion regulation in adolescents engaging in binge eating and/or purging and healthy adolescents. Furthermore, it will look at the influence of executive function on emotion regulation in this population. This study will allow us to gain further understanding of the neural basis of emotion regulation in this age group. Moreover, this study supports the need to develop new treatment approaches based on a better understanding of the brain processes associated with eating disorders.
Investigators
Cara Bohon, PhD
Assistant Professo
Stanford University
Eligibility Criteria
Inclusion Criteria
- •Ages 14-18
- •with or without current binge eating and/or purging behaviors
Exclusion Criteria
- •We exclude patients of clinically significant low weight (\<85% ideal body weight using CDC norms for height, age, and gender) and those with contraindications for MRI (e.g., orthodontia, metallic implants). Participants also will be without evidence of current or past major neurological (e.g., seizures, psychosis, head trauma) or major sensory deficit.
Outcomes
Primary Outcomes
Brain activity during cognitive control and emotion response
Time Frame: Baseline
Functional magnetic resonance imaging will be used to measure brain activity during a task where participants engage in cognitive control and respond to emotional stimuli.
Brain activity during emotion conflict
Time Frame: Baseline
Functional magnetic resonance imaging will be used to measure brain activity during a task where participants respond to images of faces with emotional expressions overlaid with an emotion word written in text. We will focus on brain response during this task when emotion face vs word are in conflict.
Brain activity during emotion regulation
Time Frame: Baseline
Functional magnetic resonance imaging will be used to measure brain activity during a task where participants attempt to regulate emotional responses.
Secondary Outcomes
- Behavioral performance on emotion conflict task(Baseline)
- Behavioral performance on emotion regulation task(Baseline)
- Behavioral performance on cognitive control and emotion regulation task(Baseline)