ovel Self-management Techniques for Early Expression of Psychopathology: An Experimental Study Linking Neural and Mental State Reactivity Phenotypes: SMARTSCAN (Self-Management of Altered environmental Reactivity Treatment SCANning) - SMARTSCA

Medisch Universitair Ziekenhuis Maastricht0 个研究点目标入组 199 人开始时间: 待定最近更新: 2024年4月29日

适应症

试验速览

暂无简介。

•All subjects for the adolescent/young adult sample will be Dutch speaking and aged 16-25 years.
•Inclusion criteria for high-fear subject sample is the presence of a specific phobia, diagnosed prior to the experiment using a structured psychiatric interview (Mini International Neuropsychiatric Interview, MINI).[25]
•Inclusion criteria for the stage 1b high-depression and psychosis subject sample are stage 1b psychopathology of depressive and or psychotic symptomatology, which is defined as moderate but subthreshold symptoms of depression using the Montgomery-Asberg Depression Rating Scale (MADRS) with a cut-off score = 10, AND/OR subthreshold symptoms of psychosis using the Community Assessment of Psychic Experiences (CAPE) with a cut-off score = 10, with moderate neurocognitive changes and functional decline to caseness (Global Assessment of Functioning [GAF] < 70).[28] Subjects with a minor depression according to DSM-IV will be included. Depression and psychosis subjects will be included at the inclusion phase as if one sample, because of the expected high co-occurrence of above cut-off scores on the CAPE and MADRS in the same subjects.
•Inclusion criteria for the the low-no psychopathology subjects are absence or below threshold severity of symptomatology, which is defined as scores below 7 on the MADRS and below 10 on the CAPE and a STAI score < 44, and GAF > 70, without a psychiatric history.

•Contra-indications for (f)MRI are use of pacemaker, metal implants, pregnancy, left-handedness or a history of claustrophobia.

发起方

Medisch Universitair Ziekenhuis Maastricht