A comparative study between two materials in the promotion of liver growth before liver surgery
- Conditions
- iver cancerCancerMalignant neoplasm of liver and intrahepatic bile ducts
- Registration Number
- ISRCTN16062796
- Lead Sponsor
- Centro Hospitalar Universitário Lisboa Central
- Brief Summary
2021 Results article in https://pubmed.ncbi.nlm.nih.gov/33825512/ (added 09/09/2021)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 60
1. Diagnosis of primary or secondary malignant tumours of the liver, documented by computed tomography or magnetic resonance imaging or biopsy of the tumor lesion
2. Indication for resection of the hepatic tumor
3. An estimated future liver remnant (FLR) less than:
3.1. 25% in healthy liver
3.2. 40% in cirrhotic liver or with severe steatosis or previous chemotherapy
4. Renal function suitable for the use of iodinated venous contrast medium:
4.1. Serum creatinine = 1.4 mg/dL
4.2. Clearance of creatinine (GFR) = 60 mL/min/1.73m2
5. Age = 18 years
1. Uncorrectable coagulopathies
2. Sectorial portal thrombosis (e.g., thrombosis of the right anterior sectorial branch)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Hepatic hypertrophy (liver volume growth) measured by computed tomography volumetry at 14 and 28 days
- Secondary Outcome Measures
Name Time Method