Comparison of fluid restriction with urea versus fluid restriction alone for inpatient management of syndrome of inappropriate antidiuretic hormone secretion (SIADH)

Not Applicable

• Conditions: Syndrome of Inappropriate ADH secretion (SIADH); Hyponatremia; Metabolic and Endocrine - Metabolic disorders

• Registration Number: ACTRN12615000379516
• Lead Sponsor: orth Shore Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-04-27
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

1. Medical patients admitted to North Shore hospital from April to July 2015
2. Acute moderate to severe hyponatremia (Na < 128) – This data will be provided daily by the biochemistry laboratory
3. Hyponatremia secondary to SIADH, as defined below
- Serum osmolality less than 280mosmol/kg
- An inappropriately elevated urine osmolality (above 100 mosmol/kg and usually above 300 mosmol/kg)
- A urine sodium concentration above 40 meq/L
- A normal serum creatinine concentration
- Normal adrenal and thyroid function
- Patient is clinically euvolemic

Exclusion Criteria

Hyponatremia with impaired consciousness or seizures
Chronic kidney disease stage 4-5
Liver cirrhosis
Congestive cardiac failure
Patients on diuretics

Study & Design

• Study Type: Interventional
• Study Design: Not specified