Brain Derived Neurotropic Factor Level and val66met Polymorphism of Brain Derived Neurotropic Factor Gene in Patients With Type Two Diabetes Mellitus and Depression
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Depression
- Sponsor
- Kasr El Aini Hospital
- Enrollment
- 88
- Locations
- 1
- Primary Endpoint
- val66met polymorphism of BDNF gene
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
This study aimed to evaluate the relation between the levels of (Brain Derived Neurotropic Factor) BDNF and val66met polymorphism of BDNF gene, and the presence of depression in type 2 diabetes. In addition to studying the relationship between BDNF level and val66met polymorphism of its gene and assessing relation between BDNF level and obesity.
Detailed Description
The study included 88 type 2 diabetic patients, which are further divided into two groups; depressed and non-depressed. Depression was assessed by Hamilton Depression Rating Scale (HAM-D) and structured clinical interview for DSM-IV Axis disorder (SCID-I) for diagnosing depression and exclusion of other psychiatric disorders. Genotyping was performed by using Real Time-PCR (TaqMan probes).
Investigators
Tarek Samy Abdelaziz
Associate professor
Kasr El Aini Hospital
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
val66met polymorphism of BDNF gene
Time Frame: 1 day (At the time of recruitment)
Measurement of val66met polymorphism of BDNF gene
BDNF level in blood
Time Frame: 1 day (At the time of recruitment)
Measurement of the level of BDNF in blood