EARLY Assessment of MYOcardial Tissue Characteristics in OBESITY (EARLY-MYO-OBESITY)
- Conditions
- Obese
- Registration Number
- NCT05277779
- Lead Sponsor
- RenJi Hospital
- Brief Summary
EARLY-MYO-OBESITY-CMR is a prospective, three-center, cardiac imaging study to investigate cardiac morphology, function, and tissue phenotypes in a cohort of non-diabetic obese adults, and compare with metabolically healthy non-obese controls.
- Detailed Description
1. Transthoracic echocardiography was performed to analyze the LV morphology and function.
2. CMR was performed within 24 hours of the echocardiographic examination to assess the cardiac morphology , cardiac function, and myocardial tissue characteristics. Standard cine images were acquired to quantify LV function and volume. T1 mapping-derived ECV values were used to detect subtle diffuse fibrosis , and late gadolinium-enhanced (LGE) imaging was used to identify focal fibrosis. Native T2 values were obtained to quantify myocardial edema . Global longitudinal peak systolic strain (GLS) and e' SR were assessed by tissue tracking analysis to detect subclinical systolic and diastolic dysfunction.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 120
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method investigate cardiac morphology and function by CMR 24 hours within recruitment cardiac morphology and function were assessed by CMR steady-state free precession sequences
investigate cardiac tissue characteristics by CMR 24 hours within recruitment myocardial edema and fibrosis were assessed by CMR T2 mapping and ECV
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Renji Hospital
🇨🇳Shanghai, Shanghai, China
Renji Hospital🇨🇳Shanghai, Shanghai, China