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临床试验/NCT05277779
NCT05277779已完成不适用

EARLY Assessment of MYOcardial Tissue Characteristics in OBESITY (EARLY-MYO-OBESITY)

RenJi Hospital1 个研究点 分布在 1 个国家目标入组 120 人开始时间: 2019年1月1日最近更新:
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适应症

试验速览

阶段
不适用
状态
已完成
入组人数
120
试验地点
1
主要终点
investigate cardiac morphology and function by CMR
研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

EARLY-MYO-OBESITY-CMR is a prospective, three-center, cardiac imaging study to investigate cardiac morphology, function, and tissue phenotypes in a cohort of non-diabetic obese adults, and compare with metabolically healthy non-obese controls.

详细描述

  1. Transthoracic echocardiography was performed to analyze the LV morphology and function.
  2. CMR was performed within 24 hours of the echocardiographic examination to assess the cardiac morphology , cardiac function, and myocardial tissue characteristics. Standard cine images were acquired to quantify LV function and volume. T1 mapping-derived ECV values were used to detect subtle diffuse fibrosis , and late gadolinium-enhanced (LGE) imaging was used to identify focal fibrosis. Native T2 values were obtained to quantify myocardial edema . Global longitudinal peak systolic strain (GLS) and e' SR were assessed by tissue tracking analysis to detect subclinical systolic and diastolic dysfunction.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 75 Years（Adult, Older Adult）
性别
All
接受健康志愿者
是

入选标准

  • 未提供

排除标准

  • 未提供

结局指标

主要结局

investigate cardiac morphology and function by CMR

时间窗: 24 hours within recruitment

cardiac morphology and function were assessed by CMR steady-state free precession sequences

investigate cardiac tissue characteristics by CMR

时间窗: 24 hours within recruitment

myocardial edema and fibrosis were assessed by CMR T2 mapping and ECV

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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EARLY Assessment of MYOcardial Tissue... | 临床试验