EUCTR2010-021384-33-SE进行中（未招募）不适用
The Effect of Naltrexone on Amphetamine Cue Reactivity: An fMRI Study
Beroendecentrum Stockholm0 个研究点开始时间: 2010年6月29日最近更新:
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- Male
入选标准
- •Men between the ages 20-55 years
- •Fulfils DSM-IV diagnosis for amphetamine dependence
- •Minimum of 2 years history of amphetamine dependence
- •History of intravenous amphetamine use
- •Consumed amphetamine for minimum of 12 times in the last 12 weeks
- •Drug free 1-30 days (minimum 24 hours)
- •Abstinent from nicotine and caffeine during the testing day
- •A healthy control group is also selected according to the following inclusion criteria:
- •Men between 20-55 years, judged to be healthy by the investigator on the basis of medical history, physical examination and vital signs.
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range 70
- •F.1.3 Elderly (>=65 years) no
- •F.1.3.1 Number of subjects for this age range
排除标准
- •Fulfils DSM-IV diagnosis of any other substance dependence disorder (except nicotine)
- •Fulfils DSM-IV diagnosis of any major psychiatric illness (e.g. bipolar affective disorder, schizophrenia)
- •Left-handedness
- •No clinical signs of amphetamine intoxication at the day of testing
- •Traces of cannabis, opiates, cocaine or benzodiazepines in the urine at the day of testing
- •Traces of alcohol as measured by breathalyser at the day of testing
- •Implant of pacemaker or any metallic object that might interfere with the magnetic field
- •Presence of severe somatic disorder (e.g. renal or hepatic failure)
- •Regular use of medication that may interact with study medication (e.g., opioid pain killers)
- •Experience with naltrexone during last six months
- •Known hypersensitivity to naltrexone
- •The healthy control group will be selected according to the following exclusion criteria:
- •Fulfils DSM IV diagnosis of any substance dependence disorder in self or in first degree relatives (parents, children or siblings)
- •Smoker (including snuff or any other nicotine product) and fulfils DSM IV diagnosis of nicotine dependence
- •Fulfils DSM IV diagnosis of any major psychiatric illness in self or in first degree relatives (parents, children or siblings)
- •Left-handedness
- •Traces of cannabis, opiates, cocaine, central amines or benzodiazepines in the urine at test day
- •Traces of alcohol as measured by breathalyzer at test day
- •Implant of pacemaker or any metallic object that might interfere with the magnetic field
- •Use of any concomitant medication
- •Known hypersensitivity to naltrexone.
研究者
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