Krill Oil and Resistance Exercise in Older Adults

Not Applicable

Completed

• Conditions: Sarcopenia
• Interventions: Dietary Supplement: Krill oil; Dietary Supplement: Vegetable oil; Other: Home-based resistance exercise

• Registration Number: NCT05869513
• Lead Sponsor: University of Glasgow

Brief Summary

The aim of this study is to determine whether krill oil supplementation enhances effects of a pragmatic resistance exercise programme on adaptations in muscle strength, mass, function and neuromuscular function in sedentary older adults. Hypothesis - krill oil supplementation will enhance the beneficial effects of resistance exercise on muscle strength, function, mass and neuromuscular function in sedentary older adults.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-05-05
• Study First Submitted: 2023-05-11
• Study First Submitted QC: 2023-05-11
• Study First Posted: 2023-05-22
• Primary Completion: 2024-02-01
• Study Completion: 2024-02-01
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-25
• Last Update Posted: 2025-03-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Over the age of 60 years
• scoring a low level of physical activity based on international physical activity questionnaire (not meeting the recommend physical activity which is at least 600 MET-min per week).

Exclusion Criteria

• Diabetes
• severe cardiovascular disease
• seizure disorders
• uncontrolled hypertension (>150/90mmHg at baseline measurement)
• cancer or cancer that has been in remission <5 years
• ambulatory impairments which would limit ability to perform assessments of muscle function
• dementia
• taking medication known to affect muscle (e.g. steroids)
• have an implanted electronic device (e.g. pacemaker/defibrillator/insulin pump)
• on anticoagulant therapy
• allergies to seafood
• regular consumption of more than 1 portion of oily fish per week
• already taking fish or krill oil or other n3 PUFA supplements
• femoral neck fracture or other severe of hip or knee operations
• stroke
• Parkinson's disease
• COPD
• kidney disease
• hyperlipidaemia
• obesity
• osteoporosis.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Krill oil + Resistance exercise	Krill oil	4g/day krill oil and home based resistance exercise for 16 weeks
Krill oil + Resistance exercise	Home-based resistance exercise	4g/day krill oil and home based resistance exercise for 16 weeks
Vegetable oil + Resistance exercise	Vegetable oil	4g/day vegetable oil and home based resistance exercise for 16 weeks
Vegetable oil + Resistance exercise	Home-based resistance exercise	4g/day vegetable oil and home based resistance exercise for 16 weeks

Primary Outcome Measures

Name	Time	Method
Nueromuscular Junction (NMJ) transmission instability	Change from baseline to 16 weeks	NMJ transmission instability will be measured by iEMG

Secondary Outcome Measures

Name	Time	Method
Red Blood Cell Omega-3 levels	Change from baseline to 16 weeks
Muscle thickness	Change from baseline to 16 weeks	Vastus Lateralis muscle thickness will be measured by ultrasound
30s chair stand test	Change from baseline to 16 weeks	measuring the functional abilities
Gait speed	Change from baseline to 16 weeks	measuring the functional abilities
Grip strength	Change from baseline to 16 weeks	Grip strength will be measured by handgrip dynamometer
Knee extensor maximal torque	Change from baseline to 8 16 weeks	Knee extensor maximal torque will be measured by a load cell
Force steadiness during submaximal isometric knee extensor contractions	Change from baseline to 16 weeks	Steadiness of force whilst contracting

Trial Locations

Locations (1)

University of Glasgow; 🇬🇧 Glasgow, United Kingdom