Investigating the Effects of Krill Oil and Krill Protein on Post-exercise Muscle Protein Metabolism
- Conditions
- Hypertrophy
- Interventions
- Dietary Supplement: Vegetable oilDietary Supplement: Krill proteinDietary Supplement: Krill oilDietary Supplement: Carbohydrate
- Registration Number
- NCT05774444
- Lead Sponsor
- University of Glasgow
- Brief Summary
The aim of the current study is to find out if krill oil can increase muscle building processes in response to resistance (weightlifting) type exercise. Others aim are to determine the effects of krill protein, and the interaction of krill oil and protein, on muscle building processes in response to resistance (weightlifting) type exercise.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 48
- Be 60 years old or older
- Have a BMI of less than 35kg/m2
- Be participating in structured exercise for less than 2h per week
- Diabetes
- Severe cardiovascular disease
- Seizure disorders,
- Uncontrolled hypertension (>150/90mmHg at baseline measurement)
- Cancer or cancer that has been in remission <5 years
- Ambulatory impairments which would limit ability to perform assessments of muscle function
- Dementia
- Taking medication known to affect muscle (e.g., steroids)
- Have an implanted electronic device (e.g., pacemaker/defibrillator/insulin pump),
- Anticoagulant therapy
- Allergies to seafood
- Regular consumption of more than 1 portion of oily fish per week.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Vegetable oil + Carbohydrate Vegetable oil The vegetable oil will be a placebo control for the Krill oil (4g/day). The carbohydrate will be a placebo control for the Krill protein (20g) Krill oil + Carbohydrate Carbohydrate The Krill oil will be the active supplement for the intervention (4g/day). The carbohydrate will be a placebo control for the Krill protein (20g) Vegetable oil + Carbohydrate Carbohydrate The vegetable oil will be a placebo control for the Krill oil (4g/day). The carbohydrate will be a placebo control for the Krill protein (20g) Vegetable oil + Krill protein Vegetable oil The vegetable oil will be a placebo control for the Krill oil (4g/day). Krill protein will be our active intervention (20g) Vegetable oil + Krill protein Krill protein The vegetable oil will be a placebo control for the Krill oil (4g/day). Krill protein will be our active intervention (20g) Krill oil + Krill protein Krill protein Both the Krill oil (4g/day) and the Krill protein will be the active intervention supplements (20g) Krill oil + Carbohydrate Krill oil The Krill oil will be the active supplement for the intervention (4g/day). The carbohydrate will be a placebo control for the Krill protein (20g) Krill oil + Krill protein Krill oil Both the Krill oil (4g/day) and the Krill protein will be the active intervention supplements (20g)
- Primary Outcome Measures
Name Time Method Post-exercise muscle protein synthesis 3-7 hours Muscle protein synthesis measured 3-7h after a single bout of resistance exercise
- Secondary Outcome Measures
Name Time Method Change in Muscle thickness Change from baseline to 8 weeks Vastus lateralis muscle thickness measured by ultrasound
Change in grip strength Change from baseline to 8 weeks Grip strength measured with a Jamar dynamometer
Change in fat mass Change from baseline to 8 weeks Whole body fat mass measured by BIA
Change in muscle strength Change from baseline to 8 weeks Knee extensor muscle strength measured isometrically
Change in lean mass Change from baseline to 8 weeks Whole body lean mass measured by BIA
Change in Chair rise time Change from baseline to 8 weeks Time taken to get up and down from a chair 5 times
Change in Erythrocyte fatty acid profile Change from baseline to 8 weeks Erythrocyte fatty acid profile
Change in balance Change from baseline to 8 weeks Ability to stand for 10 seconds in full tandem, semi-tandem and feet together
Change in gait speed Change from baseline to 8 weeks Time taken to walk 4 metres at a normal walking pace
Basal muscle protein synthesis 0-3 hours Muscle protein synthesis measured from 0-3h after an overnight fast
Trial Locations
- Locations (1)
Stuart Robert Gray
🇬🇧Glasgow, United Kingdom