Middle Age MuScle Krill Study

Not Applicable

Recruiting

• Conditions: Sarcopenia
• Interventions: Dietary Supplement: Vegetable oil; Dietary Supplement: Krill oil

• Registration Number: NCT06005064
• Lead Sponsor: University of Glasgow

Brief Summary

This study will determine the effect of 6 months of supplementation with krill oil on muscle strength and mass in middle-aged adults. The study hypothesis is that krill oil supplementation will increase muscle strength and mass in middle-aged adults.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-08-16
• Study First Submitted QC: 2023-08-16
• Study First Posted: 2023-08-22
• Study Start: 2023-11-01
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-25
• Last Update Posted: 2025-03-30
• Primary Completion: 2025-06
• Study Completion: 2025-10

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 92

Inclusion Criteria

• Be 35-60 years old
• Have a BMI of less than 35kg/m2

Exclusion Criteria

• People with diabetes, severe cardiovascular disease, seizure disorders, uncontrolled hypertension (>150/90mmHg at baseline measurement), cancer or cancer that has been in remission <5 years, ambulatory impairments which would limit the ability to perform assessments of muscle function, dementia, on anticoagulant therapy, and/or taking medication known to affect muscle (e.g., steroids).
• People who have allergies to seafood, and/or regular consumption of more than 1 portion of oily fish per week.
• People who perform regular (>1 day/week) resistance exercise training.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo	Vegetable oil	Vegetable oil 4g/day for 24 weeks
Intervention	Krill oil	Krill oil 4g/day for 24 weeks

Primary Outcome Measures

Name	Time	Method
Change in knee extensor maximal isometric torque ( MVC)	Change from baseline to 24 weeks	Knee extensor maximal isometric torque measured during a maximal voluntary contraction

Secondary Outcome Measures

Name	Time	Method
Change in omega-3 levels	Change from baseline to 24 weeks	Red blood cell omega-3 levels
Change in Grip strength	Change from baseline to 24 weeks	Grip strength measured with a hand held dynamometer
Change in fat mass	Change from baseline to 24 weeks	Whole body fat mass measured by measured via bio-electrical impedance
Change in lean mass	Change from baseline to 24 weeks	Whole body lean mass measured by measured via bio-electrical impedance
Change in Muscle thickness	Change from baseline to 24 weeks	Vastus lateralis muscle thickness measured by ultrasound

Trial Locations

Locations (1)

University of Glasgow; 🇬🇧 Glasgow, United Kingdom