A Comparison of the Effects of Krill Oil and Fish Oil Supplementation on Muscle Function in Older Adults

Not Applicable

Completed

• Conditions: Sarcopenia
• Interventions: Dietary Supplement: Vegetable oil; Dietary Supplement: Fish oil; Dietary Supplement: Kril oil

• Registration Number: NCT05869526
• Lead Sponsor: University of Glasgow

Brief Summary

The aim of the study is to compare the effects of Krill Oil and Fish Oil supplementation on muscle function in older adults. The secondary aim is to investigate the mechanisms underlying the beneficial effects previously observed.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-05-01
• Study First Submitted: 2023-05-11
• Study First Submitted QC: 2023-05-11
• Study First Posted: 2023-05-22
• Primary Completion: 2024-02-01
• Study Completion: 2024-04-01
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-25
• Last Update Posted: 2025-03-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 61

Inclusion Criteria

• Older adults (aged 60 years or older). BMI less than 30kg/m2

Exclusion Criteria

• Participants (diagnosed and being treated for a pre-existing medical condition (cancer, kidney disease, liver disease, diabetes mellitus and cardiovascular disease, uncontrolled hypertension, gait disturbances limiting the ability to perform assessments of muscle function, dementia, affecting muscles known to use drugs (e.g., steroids). History of allergy to fish or fish oil and regular consumption of more than1portion of oily fish per week or use of fish oil or krill oil supplements will also be excluded.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo	Vegetable oil	Vegetable oil 4g/day
Fish oil	Fish oil	Fish oil 4 g/day
Krill oil	Kril oil	Krill oil 4g/day

Primary Outcome Measures

Name	Time	Method
Change in knee extensor maximal isometric torque ( MVC)	Change from baseline to 16 weeks	Knee extensor maximal isometric torque measured during a maximal voluntary contraction

Secondary Outcome Measures

Name	Time	Method
Change in fat mass	Change from baseline to 16 weeks	Whole body fat mass measured by measured via bio-electrical impedance
Blood sample	Change from baseline to 16 weeks	Red Blood Cell Omega-3 levels
Change in Muscle thickness	Change from baseline to 16 weeks	Vastus lateralis muscle thickness measured by ultrasound
Neuromuscular Junction (NMJ)	Change from baseline to 16 weeks	Measured by iEMG
Change in gait speed	Change from baseline to 16 weeks	Time taken to walk 4 metres at a normal walking pace
Change in Grip strength	Change from baseline to 16 weeks	Grip strength measured with a hand held dynamometer
Force steadiness during submaximal isometric knee extensor contractions	Change from baseline to 16 weeks	Measured by using intramuscular iEMG
Change in lean mass	Change from baseline to 16 weeks	Whole body lean mass measured by measured via bio-electrical impedance
Change in Chair rise time	Change from baseline to 16 weeks	A 30-second sit-to-stand test measured functional abilities

Trial Locations

Locations (1)

Stuart Robert Gray; 🇬🇧 Glasgow, Scotland, United Kingdom