Krill Oil and Muscle in Older Adults

Not Applicable

Completed

• Conditions: Aging; Sarcopenia
• Interventions: Dietary Supplement: Placebo; Dietary Supplement: Krill Oil

• Registration Number: NCT04048096
• Lead Sponsor: University of Glasgow

Brief Summary

The aim of this study is to determine the effects of krill oil supplementation on muscle mass in function in older adults. Half of the participants will receive krill oil supplements and the other half a placebo.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-03-07
• Study First Submitted: 2019-07-26
• Study First Submitted QC: 2019-08-05
• Study First Posted: 2019-08-07
• Primary Completion: 2020-03-10
• Study Completion: 2020-03-10
• Status Verified: 2020-11
• Last Update Submitted: 2020-11-02
• Last Update Posted: 2020-11-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 102

Inclusion Criteria

• BMI less than 35kg/m2

Exclusion Criteria

• Diabetes
• severe cardiovascular disease
• seizure disorders
• uncontrolled hypertension (>150/90mmHg at baseline measurement)
• cancer or cancer that has been in remission <5 years
• ambulatory impairments which would limit ability to perform assessments of muscle function
• dementia
• taking medication known to affect muscle (e.g. steroids)
• have an implanted electronic device (e.g. pacemaker/defibrillator/insulin pump)
• on anticoagulant therapy
• allergies to seafood
• regular consumption of more than 2 portions of oily fish per week.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo	Placebo	4g/day of mixed vegetable oil supplements
Krill	Krill Oil	4g/day krill oil

Primary Outcome Measures

Name	Time	Method
Change in Muscle strength	Change from baseline to 6 months	knee extensor muscle strength

Secondary Outcome Measures

Name	Time	Method
Change in Short performance physical battery test	Change from baseline to 6 months	SPPB
Change in Body Fat	Change from baseline to 6 months	Measured by BIA
Change in Lean Mass	Change from baseline to 6 months	Measured by BIA
Change in Grip strength	Change from baseline to 6 months	Grip strength
Change in Fasting glucose	Change from baseline to 6 months	Fasting glucose
Change in CRP	Change from baseline to 6 months	CRP
Change in Muscle thickness	Change from baseline to 6 months	Vastus lateralis muscle thickness
Change in Blood lipids	Change from baseline to 6 months	Blood lipids
Change in Erythrocyte fatty acid profile	Change from baseline to 6 months	Erythrocyte fatty acid profile

Trial Locations

Locations (1)

Stuart Robert Gray; 🇬🇧 Glasgow, United Kingdom