The Effect of Creatine on Muscle Loss

Not Applicable

Completed

• Conditions: Muscle Loss
• Interventions: Other: Placebo supplementation; Other: Creatine supplementation

• Registration Number: NCT01894737
• Lead Sponsor: Maastricht University Medical Center

Brief Summary

The primary aim of this study is to determine the effect of creatine supplementation on muscle mass loss during short-term immobilisation in healthy, young people.

Detailed Description

Seven days of one-legged knee immobilisation in young subjects with creatine or Placebo supplementation. A randomly selected leg is immobilized for seven days. Muscle mass and strength will be determined and muscle biopsies will be collected before and immediately after immobilisation. A week after the cast is removed we will assess any differences in recovery between intervention groups.

Study Timeline

• Study First Submitted: 2013-07-01
• Study First Submitted QC: 2013-07-09
• Study First Posted: 2013-07-10
• Study Start: 2013-10
• Primary Completion: 2015-04
• Study Completion: 2015-04
• Status Verified: 2015-08
• Last Update Submitted: 2015-08-28
• Last Update Posted: 2015-08-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 30

Inclusion Criteria

• Male
• Aged from 18-35 years
• 18.5 < BMI < 30 kg/m2

Exclusion Criteria

• (Family) history of thrombosis
• Smoking
• Recent surgery
• Performing regular resistance training more than once per week in the past year
• Any back/leg/knee/shoulder complaints which may interfere with the use of crutches
• Current systemic use of corticosteroids, growth hormone, testosterone, immunosuppressants or insulin
• All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis)
• Use of anti-coagulants
• Pre-existing renal disease or those with a potential risk for renal dysfunction (diabetes, hypertension, reduced glomerular filtration rate)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
immobilisation and placebo	Placebo supplementation	Seven days of one-legged knee immobilisation with placebo supplementation
immobilisation and creatine	Creatine supplementation	Seven days of one-legged knee immobilisation with creatine supplementation

Primary Outcome Measures

Name	Time	Method
change in quadriceps muscle cross-sectional area (CSA)	Before and after 1 week of immobilisation, and after 1 week of recovery	immediately before and after 1 week of immobilisation, and after 1 week recovery, quadriceps CSA will be assessed

Secondary Outcome Measures

Name	Time	Method
change in muscle strength	before and after 1 week of immobilisation, and after 1 week of recovery	immediately before and after 1 week of immobilization, and after 1 week of natural recovery, one-repetition maximum (1RM) muscle strength will be assessed
change in muscle fiber type specific CSA	Before and after 1 week of immobilisation, and after 1 week of recovery	immediately before and after 1 week of immobilization, and after 1 week of natural recovery

Trial Locations

Locations (1)

Maastricht University Medical Centre+; 🇳🇱 Maastricht, Limburg, Netherlands