Creatine Supplementation in Pediatric Rheumatology
Not Applicable
- Conditions
- Juvenile DermatomyositisJuvenile Systemic Lupus Erythematosus
- Interventions
- Dietary Supplement: creatineDietary Supplement: placebo (dextrose)
- Registration Number
- NCT01217320
- Lead Sponsor
- University of Sao Paulo
- Brief Summary
Creatine supplementation may improve strength, muscle mass, bone mass and muscle function in healthy and elderly people. The investigators speculate that creatine supplementation could have therapeutic effects in pediatric rheumatic (i.e., juvenile systemic lupus erythematosus and juvenile dermatomyositis) patients who usually present muscle weakness, muscle wasting and bone mass loss.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- patients diagnosed with lupus systemic erythematosus and juvenile dermatomyositis
- physically inactive
- stable pharmacological treatment
Exclusion Criteria
- macroalbuminuria
- GFR < 30 mL/min/1.73m2
- use of oral anticontraceptive agents
- pregnancy
- diabetes mellitus
- hypothyroidism
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description creatine supplementation creatine will receive 5g/d of creatine monohydrate throughout the trial placebo placebo (dextrose) will receive 5g/d of placebo (dextrose) throughout the trial
- Primary Outcome Measures
Name Time Method muscle strength after six months
- Secondary Outcome Measures
Name Time Method muscle function after six months kidney function parameters after six months quality of life after six months
Trial Locations
- Locations (1)
University of Sao Paulo
🇧🇷Sao Paulo, Brazil