The Effect of Creatine Supplementation on Muscle Loss During Immobilisatio

Completed

• Conditions: Disuse atrophy; 10028302

• Registration Number: NL-OMON40238
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2015-04-08
• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

Male
Aged from 18-35 years
18.5 < BMI < 30 kg/m2

Exclusion Criteria

(Family) history of thrombosis
Smoking
Recent surgery < 6 months
Performing regular resistance training more than once per week in the past year
Any back/leg/knee/shoulder complaints which may interfere with the use of crutches
Current systemic use of corticosteroids, growth hormone, testosterone, immunosuppressants or insulin
All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis)
Use of anti-coagulants
Pre-existing renal disease or those with a potential risk for renal dysfunction (diabetes, hypertension, reduced glomerular filtration rate)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>quadriceps muscle CSA</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>whole upper leg muscle CSA<br /><br>muscle fiber type specific CSA<br /><br>muscle fiber type-specific satellite cell content<br /><br>1RM muscle strength</p><br>