Clinical Study of Guangsi Yulin Decoction's Effect on Sperm DNA Fragmentation Index of asthenospermia patients

Phase 1

• Conditions: Asthenospermia

• Registration Number: ITMCTR2000004121
• Lead Sponsor: Dongzhimen Hospital, Beijing University of Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Pending
• Sex: Male
• Target Recruitment: Not specified

Inclusion Criteria

(1) Meet the western medical diagnostic criteria of male infertility and asthenospermia, and have the two diagnoses at the same time;
(2) TCM syndrome differentiation conforms to kidney deficiency syndrome;
(3) Male aged 22 to 45 years;
(4) Married, husband and wife have a harmonious family relationship;
(5) Sperm DNA fragmentation index (DFI) >=30%;
(6) No other organic lesions of the reproductive system;
(7) Those who did not receive treatment with similar drugs or other therapies within 2 weeks before the study;
(8) Understand the content of the study and sign the informed consent.
Those who meet the above 8 criteria at the same time will be included in the study; otherwise, they will not be included

Exclusion Criteria

(1) According to the Manual of Human Semen Examination and Treatment Laboratory, edition 5, except for total sperm motility < 40% and forward motility < 32%, there are other abnormalities in semen examination;
(2) Patients with a family history of genetic diseases;
(3) Suffering from varicocele, prostatitis and other diseases that lead to sperm quality decline;
(4) Patients with active infection;
(5) Patients with severe primary diseases such as cardiovascular, liver, kidney and hematopoietic system;
(6) Patients with mental disorders;
(7) Patients who have a long-term and large amount of smoking and drinking habits, or are exposed to high temperature, radiation and toxic chemical environment, but cannot change or give up;
(8) Allergic constitution and allergic to multiple drugs.
Meeting any of the above is considered as meeting the exclusion criteria, and exclusion is required.Those who meet the above 8 criteria at the same time will be included in the study; otherwise, they will not be included

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Semen routine;