Evaluating Patient Knowledge About Perioperative Neurocognitive Disorders (KNOW-PND Study)

Recruiting

• Conditions: Anesthesia Complication

• Registration Number: NCT05590845
• Lead Sponsor: Université Libre de Bruxelles

Brief Summary

Neurocognitive disorders remain one of the major perioperative complications. They are associated with delayed recovery, prolonged length of hospital stay and impacts on patients' quality of life. The incidence of PND ranges from 15-50%.

While several causes have been investigated, PND seems to be due to the non-resolution of an inflammatory cascade, making some patients more at risk than others. As such, major risk factors include old age and lower education levels.

As the global proportion of people aged 60 and above between 2015 and 2050 will increase from 12% to 22% and worldwide surgeries increases to \>300 million procedures per annum the incidence of perioperative neurocognitive disorders with high morbidity and mortality will go up.

In 2015, the American Society of Anesthesiologists (ASA) launched the 'Perioperative Brain Health Initiative' to increase awareness about perioperative neurocognitive disorders. (PND) While physicians seems to be more and more aware about this condition, data regarding patient awareness are not available.

An observational, single-centre, cross-sectional survey study (with initially a feasibility study) will be conducted in patients, 65 years and above undergoing elective total hip replacement surgery at AZ Sint-Jan (Brugge, Belgium) to assess patients' basic knowledge regarding PND.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-10-18
• Study First Submitted QC: 2022-10-18
• Study First Posted: 2022-10-21
• Study Start: 2023-01-15
• Status Verified: 2024-05
• Last Update Submitted: 2024-12-03
• Last Update Posted: 2024-12-06
• Primary Completion: 2024-12-15
• Study Completion: 2024-12-15

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• age 65 and above
• ASA score 1 to 3
• scheduled for elective hip surgery.

Exclusion Criteria

• insufficient knowledge of Dutch
• known neuropsychiatric conditions

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
PND knowledge	1 week pre-operatively	Patient knowledge regarding PND will be evaluated through 15 yes/no questions

Secondary Outcome Measures

Name	Time	Method
Baseline cognition	1 week pre-operatively	Baseline T-moca scores will be documented in order to evaluate PND presence.
PND	6 weeks post-operatively	T-moca scores will be documented post-operatively (and compared to baseline scores) in order to evaluate PND presence.

Trial Locations

Locations (1)

AZ Sint-Jan Brugge Oostende AV; 🇧🇪 Brugge, Belgium