Effect of Endometrial Thickness on IVF Outcome

• Conditions: Infertility
• Interventions: Procedure: Embryo transfer

• Registration Number: NCT02420704
• Lead Sponsor: The First Affiliated Hospital of Zhengzhou University

Brief Summary

Although many studies have evaluated the relationship between endometrial thickness and IVF outcome, the results are still controversial. We notice that, during our daily work, for patients undergoing cleavage stage embryo transfer, endometrial thickness seems to have a huge impact on IVF outcome; however, for blastocyst stage embryo transfers, IVF outcome seems to have little association with endometrial thickness. Thus, the aim of this prospective observational study is to explore the relationship between endometrial thickness and IVF outcome in patients undergoing cleavage stage and blastocyst stage embryo transfers, respectively.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-11
• Status Verified: 2015-04
• Study First Submitted: 2015-04-15
• Study First Submitted QC: 2015-04-17
• Last Update Submitted: 2015-04-18
• Study First Posted: 2015-04-20
• Last Update Posted: 2015-04-21
• Primary Completion: 2015-10
• Study Completion: 2015-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 500

Inclusion Criteria

• age between 22-38 years old;
• the first cycle of IVF treatment with standard long protocol;
• transfrred with at least two high quality cleavage stage embryos, or with at least one high quality blastocyst stage embryo.

Exclusion Criteria

• PGD cycles;
• gamete donation cycles

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Blastocyst stage-thick endometrial	Embryo transfer	Patients transferred with blastocyst stage embryo, with endometrial thickness ≥14mm on the day of HCG (human chorionic gonadotropin) administration for fresh cycles, or on the day starting to use progesterone for frozen thawed cycles.
Blastocyst stage-medium endometrial	Embryo transfer	Patients transferred with blastocyst stage embryo, with endometrial thickness 8-13mm on the day of HCG (human chorionic gonadotropin) administration for fresh cycles, or on the day starting to use progesterone for frozen thawed cycles.
Cleavage stage-thick endometrial	Embryo transfer	Patients transferred with cleavage stage embryo, with endometrial thickness ≥14mm on the day of HCG (human chorionic gonadotropin) administration for fresh cycles, or on the day starting to use progesterone for frozen thawed cycles.
Cleavage stage-thin endometrial	Embryo transfer	Patients transferred with cleavage stage embryo, with endometrial thickness ≤7mm on the day of HCG (human chorionic gonadotropin) administration for fresh cycles, or on the day starting to use progesterone for frozen thawed cycles.
Cleavage stage-medium endometrial	Embryo transfer	Patients transferred with cleavage stage embryo, with endometrial thickness 8-13mm on the day of HCG (human chorionic gonadotropin) administration for fresh cycles, or on the day starting to use progesterone for frozen thawed cycles.
Blastocyst stage-thin endometrial	Embryo transfer	Patients transferred with blastocyst stage embryo, with endometrial thickness ≤7mm on the day of HCG (human chorionic gonadotropin) administration for fresh cycles, or on the day starting to use progesterone for frozen thawed cycles.

Primary Outcome Measures

Name	Time	Method
Ongoing pregnancy rate	12 weeks after embryo transfer	An ongoing pregnancy was defined as a pregnancy with a positive heartbeat by ultrasound after 12 weeks gestation.

Trial Locations

Locations (1)

Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University; 🇨🇳 Zhengzhou, Henan, China