Observation of Blood Orphanin and Norepinephrine Levels in Diabetic Patients Under Subarachnoid Anesthesia

Completed

• Conditions: Intraspinal Anesthesia
• Interventions: Diagnostic Test: ELISA

• Registration Number: NCT04071834
• Lead Sponsor: Second Hospital of Shanxi Medical University

Brief Summary

This study aims to investigate the Influence of Intraspinal anesthesia to the concentrations of blood orphanin, norepinephrine in patients with diabetes mellitus. We hope to explain the relationship between sensory and sympathetic nerves in diabetic patients undergoing intraspinal anesthesia.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-08-26
• Study First Submitted QC: 2019-08-26
• Study First Posted: 2019-08-28
• Study Start: 2019-10-01
• Primary Completion: 2020-04-02
• Status Verified: 2020-06
• Study Completion: 2020-06-01
• Last Update Submitted: 2020-06-30
• Last Update Posted: 2020-07-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• Patients undergoing lower limb surgery under spinal anesthesia

Exclusion Criteria

• Emergency surgery
• The operation time is more than 3 hours
• Combined general anesthesia or nerve block anesthesia

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Diabetes mellitus group	ELISA	Diabetic patients undergoing spinal anesthesia for lower extremity surgery
Non-diabetic group	ELISA	Non-diabetic patients undergoing spinal anesthesia for lower extremity surgery

Primary Outcome Measures

Name	Time	Method
Blood orphanin concentration	24 hours	Concentration of blood orphanin in patients before and after anesthesia
Blood norepinephrine concentration	24 hours	Concentration of blood norepinephrine in patients before and after anesthesia

Trial Locations

Locations (1)

Second of Shanxi Medical University; 🇨🇳 Taiyuan, Shanxi, China