Effectiveness of extended dose of tranexamic acid for 48 hours vs single dose perioperative tranexamic acid on reduction of blood loss after primary total knee arthroplasty: A randomized controlled trial
- Conditions
- Total knee replacementOral tranexamic acid
- Registration Number
- TCTR20190114001
- Lead Sponsor
- Faculty of Medicine, Prince of Songkla university
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending (Not yet recruiting)
- Sex
- All
- Target Recruitment
- 94
Patients undergoing primary unilateral total knee arthroplasty
Diagnosis of primary osteoarthritis of knee
Age less than 85 years old
1.Previous surgery around the affected knee
2.Complex TKA requiring the use of stemmed prosthesis
3.Use of anticoagulant at the time of admission
4.Documented allergy to drug in the study
5.History of deep vein thrombosis or pulmonary embolism
6.Abnormal coagulation at admission
International normalized ration > 1.5
Partial thromboplastin time > 1.4x normal
Platelet < 50,000/microL
7.Abnormal liver function test
Aspartate transaminase/Alanine transaminase > 3x normal
Alkaline phosphatase > 5x normal
8.Calculated glomerular filtration rate < 30 mL/min
9.History of acute coronary syndrome or cerebrovascular accident in the past 12 months
10.Active cancer
11.Use of drug with interaction with Tranexamic acid; eg. Tretinoin, Estrogen, Oral contraceptive pill
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Total blood loss 72 hour ml
- Secondary Outcome Measures
Name Time Method Hb level 24 hr , 72 hr g/L,Blood tranfusion 72 hr unit