A Safety and Efficacy Study of Relamorelin in Diabetic Gastroparesis 01
- Conditions
- GastroparesisDiabetes Mellitus
- Interventions
- Drug: Placebo
- Registration Number
- NCT03285308
- Lead Sponsor
- Allergan
- Brief Summary
This study will evaluate the safety and efficacy of relamorelin compared to placebo in participants with diabetic gastroparesis. Participants will report daily severity scores of their diabetic gastroparesis symptoms.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 336
- Diagnosis of Type 1 or Type 2 diabetes mellitus
- Meet the per protocol criteria of diabetic gastroparesis
- Compliance with diary
- Compliance with the per protocol study treatment dosing instructions
- Currently receiving nutrition intravenously, by nasogastric tube, or other feeding tube
- Actively experiencing anorexia nervosa, binge-eating, bulimia, or other eating disorder at the time of Screening (Visit 1)
- Diagnosis of Celiac Disease, also a history of non-celiac gluten sensitivity
- History of gastrointestinal disorders that may be similar to gastroparesis
- Functional dyspepsia diagnosed before the diagnosis of diabetes mellitus
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo Following a 2-week placebo run-in, participants received placebo-matching relamorelin injected subcutaneously twice daily for up to 12 weeks. Relamorelin 10 μg Relamorelin Following a 2-week placebo run-in, participants received relamorelin 10 μg injected subcutaneously twice daily for up to 12 weeks.
- Primary Outcome Measures
Name Time Method Percentage of Participants Meeting the Vomiting Responder Criterion During Each of the Last 6 Weeks of the 12-week Treatment Period Week 6 to Week 12 The number of vomiting episodes in the previous 24 hours were assessed daily by the participant using the DGSSD and were recorded in the e-diary. A Vomiting Responder was defined as a participant with zero weekly vomiting episodes during each of the last 6 weeks of the 12-week Treatment Period.
Change From Baseline to Week 12 in the Weekly Diabetic Gastroparesis Symptom Severity Score (DGSSS) Baseline (Day-14 to Day-1) to Week 12 Participants assessed the severity of diabetic gastroparesis symptoms daily using the Diabetic Gastroparesis Symptom Severity Diary (DGSSD), recorded in an electronic diary (e-diary). The DGSSS was derived as the sum of the weekly averages of the 4 DGSSD items: nausea, abdominal pain, postprandial fullness and bloating. Each symptom was scored using an 11-point ordinal scale where: 0=no or not at all uncomfortable to 10=worst possible or most uncomfortable for a total possible DGSSS of 0 (best) to 40 (worst). A negative change from Baseline indicates improvement. Baseline was defined as the average of the 2 weekly DGSSS from the Run-in Period.
- Secondary Outcome Measures
Name Time Method Percentage of Participants Meeting the Abdominal Pain Responder Criterion During Each of the Last 6 Weeks of the 12-week Treatment Period Baseline (Day-14 to Day-1) to (Week 6 to Week 12) An Abdominal Pain Responder was defined as a participant with an improvement (decrease) of at least 2-points in the weekly symptom scores for abdominal pain at each of the last 6 weeks of the 12-week Treatment Period. Abdominal pain was one of the items of the DGSSD assessed daily and recorded in the e-diary by the participant using an 11-point ordinal scale where: 0=no abdominal pain to 10=the worst possible abdominal pain and was recorded in an e-diary.
Percentage of Participants Meeting the Bloating Responder Criterion During Each of the Last 6 Weeks of the 12-week Treatment Period Baseline (Day-14 to Day-1) to (Week 6 to Week 12) A Bloating Responder was defined as a participant with an improvement (decrease) of at least 2-points in the weekly symptom scores for bloating at each of the last 6 weeks of the 12-week Treatment Period. Bloating was one of the items of the DGSSD assessed daily and recorded by the participant in the e-diary using an 11-point ordinal scale where: 0=no bloating and 10=the worst possible bloating and was recorded in the e-diary.
Number of Participants With Clinically Meaningful Trends for Vital Signs Up to 12 weeks Vital Signs included assessments of heart rate, respiratory rate, systolic and diastolic blood pressure, and body temperature. The investigator determined if the results were clinically significant.
Percentage of Participants Meeting the Nausea Responder Criterion During Each of the Last 6 Weeks of the 12-week Treatment Period Baseline (Day-14 to Day-1) to (Week 6 to Week 12) A Nausea Responder was defined as a participant with improvement (decrease) of at least 2-points in the weekly symptom scores for nausea at each of the last 6 weeks of the 12-week Treatment Period. Nausea was one of the items of the DGSSD assessed daily and recorded in the e-diary by the participant using an 11-point ordinal scale where: 0=no nausea to 10=worst possible nausea.
Number of Participants With Anti-relamorelin Antibody Testing Results by Visit Baseline (Day 1), Day 14, Day 28, Day 84, and End of Treatment (Up to Day 84) A blood sample was collected that was sent to a laboratory for an anti-relamorelin antibody screening test. A positive screening test was confirmed by an immunodepletion assay. The number of participants in each of the following categories are reported: Negative Screening Test, Positive Screening Test, Negative Confirmatory Test, and Positive Confirmatory Test at each time point.
Percentage of Participants Meeting the Postprandial Fullness Responder Criterion During Each of the Last 6 Weeks of the 12-week Treatment Period Baseline (Day-14 to Day-1) to (Week 6 to Week 12) A Postprandial Fullness Responder was defined as a participant with an improvement (decrease) of at least 2-points in the weekly symptom scores for Postprandial Fullness at each of the last 6 weeks of the 12-week Treatment Period. Postprandial Fullness was one of the items of the DGSSD assessed daily and recorded by the participant in the e-diary using an 11-point ordinal scale where: 0=no feeling of fullness until finishing a meal (best) to 10=feeling full after only a few bites (worst).
Number of Participants Who Experienced One or More Treatment-Emergent Adverse Events (TEAE) Up to approximately 16 weeks An adverse event (AE) is any untoward medical occurrence in a patient or clinical study participant, temporally associated with the use of study treatment, whether or not considered related to the study treatment. An AE can therefore be any unfavorable and unintended sign (including an abnormal laboratory finding), symptom, or disease (new or exacerbated) temporally associated with the use of study treatment. A TEAE is an AE that begins or worsens after receiving study drug.
Number of Participants With Potential Clinically Significant (PCS) Clinical Laboratory Results Up to 12 weeks Clinical Laboratory tests included Hematology, Chemistry and Urinalysis tests. The investigator determined if the results were clinically significant. Only those categories where at least 1 person had a non-PCS value at Baseline and met the PCS criterion at least once during postbaseline are reported.
Number of Participants With a ≥1% Increase in Glycosylated Hemoglobin A1c (HBA1c) Baseline (Day 1) up to 12 weeks HbA1c is also known as glycosylated hemoglobin. It is the concentration of glucose bound to hemoglobin as a percentage of the absolute maximum that can be bound.
Number of Participants With Clinically Significant Abnormal Electrocardiogram (ECG) Results Up to 12 weeks A standard 12-lead ECG was performed. The investigator determined if the abnormal results were clinically significant.
Trial Locations
- Locations (205)
Digestive Health Specialist of the South East
🇺🇸Dothan, Alabama, United States
Aurora Care Clinic, LLC
🇺🇸Costa Mesa, California, United States
Savin Medical Group LLC
🇺🇸Miami Lakes, Florida, United States
Southwest Gastroenterology
🇺🇸Oak Lawn, Illinois, United States
MNGI Digestive Health
🇺🇸Coon Rapids, Minnesota, United States
Montana Medical Research
🇺🇸Missoula, Montana, United States
Long Island Gastrointestinal Research Group LLP
🇺🇸Great Neck, New York, United States
Asheville Gastroenterology Associates
🇺🇸Asheville, North Carolina, United States
Endocrinology Research Associates, Inc.
🇺🇸Columbus, Ohio, United States
Preferred Primary Care Physicians, Inc.
🇺🇸Pittsburgh, Pennsylvania, United States
Amir Ali Hassan, MD, PA
🇺🇸Houston, Texas, United States
West Virginia University
🇺🇸Morgantown, West Virginia, United States
Advanced Clinical Research
🇺🇸West Jordan, Utah, United States
Verity Research Inc.
🇺🇸Fairfax, Virginia, United States
Royal Adelaide Hospital - Central Adelaide Local Health Network Incorporated
🇦🇺Adelaide, South Australia, Australia
Bhatia Hospital
🇮🇳Mumbai, Maharashtra, India
B. J. Government Medical College and Sassoon General Hospitals
🇮🇳Pune, Maharashtra, India
Universal Hospital
🇮🇳Pune, Maharashtra, India
Noble Hospital Pvt. Ltd
🇮🇳Pune, Maharashtra, India
Diabetic Thyroid and Endocrine Centre
🇮🇳Jaipur, Rajasthan, India
Marudhar Hospital
🇮🇳Jaipur, Rajasthan, India
Eternal Hospital - Diabetology
🇮🇳Jaipur, Rajasthan, India
APF Research LLC
🇺🇸Miami, Florida, United States
AMPM Research Clinic
🇺🇸Miami, Florida, United States
Advanced Medical Research Institute
🇺🇸Miami, Florida, United States
Florida Research Center, Inc.
🇺🇸Miami, Florida, United States
Indiana University Health University Hospital
🇺🇸Indianapolis, Indiana, United States
Medical Associates Research Group, Inc
🇺🇸San Diego, California, United States
Clinical Applications Laboratories, Inc.
🇺🇸San Diego, California, United States
Excel Clinical Research
🇺🇸Las Vegas, Nevada, United States
Advanced Biomedical Research of America
🇺🇸Las Vegas, Nevada, United States
Palm Research Center
🇺🇸Las Vegas, Nevada, United States
Clinical Research of South Nevada
🇺🇸Las Vegas, Nevada, United States
Digestive Disease Specialists
🇺🇸Las Vegas, Nevada, United States
Vinnytsia Regional Clinical highly specialized Endocrinology Centre
🇺🇦Vinnytsia, Ukraine
Denver Esophageal and Stomach Center
🇺🇸Englewood, Colorado, United States
S R Kalla (SRK) Memorial Gastro & General Hospital
🇮🇳Jaipur, Rajasthan, India
M.V. Hospital for Diabetes & Diabetes Research Centre
🇮🇳Chennai, Tamil Nadu, India
Cotton-O'Neil Clinical Research Center - Digestive Health
🇺🇸Topeka, Kansas, United States
SMS Hospital
🇮🇳Jaipur, Rajasthan, India
Sagact Pllc
🇺🇸San Antonio, Texas, United States
Clinical Trials of Texas, Inc.
🇺🇸San Antonio, Texas, United States
Phoenix Clinical LLC
🇺🇸Phoenix, Arizona, United States
Memorial Clinical Research
🇺🇸Oklahoma City, Oklahoma, United States
Quality Medical Research
🇺🇸Nashville, Tennessee, United States
University of Alabama at Birmingham
🇺🇸Birmingham, Alabama, United States
Northwest Gastroenterology Clinic, LLC
🇺🇸Portland, Oregon, United States
University of South Florida
🇺🇸Tampa, Florida, United States
West Central Gastroenterology
🇺🇸Tampa, Florida, United States
Del Sol Research Management, LLC
🇺🇸Tucson, Arizona, United States
University of Colorado, Denver
🇺🇸Aurora, Colorado, United States
University of Louisville
🇺🇸Louisville, Kentucky, United States
The Center for Clinical Research
🇺🇸Winston-Salem, North Carolina, United States
Synexus Clinical Research US, Inc.
🇺🇸Murray, Utah, United States
Avant Research Associates
🇺🇸Huntsville, Alabama, United States
Preferred Research Partners, Inc.
🇺🇸Little Rock, Arkansas, United States
Kindred Medical Institute for Clinical Trials, LLC
🇺🇸Corona, California, United States
Citrus Valley Gastroenterology Clinic
🇺🇸Covina, California, United States
University of California San Diego
🇺🇸La Jolla, California, United States
Hope Clinical Research
🇺🇸Canoga Park, California, United States
VVCRD Research
🇺🇸Garden Grove, California, United States
Synexus Clinical Research, US, Santa Rosa
🇺🇸Santa Rosa, California, United States
Om Research LLC
🇺🇸Lancaster, California, United States
Upland Clinical Research
🇺🇸Upland, California, United States
Connecticut Clinical Research Foundation
🇺🇸Bristol, Connecticut, United States
Innovative Research of West FL, Inc.
🇺🇸Clearwater, Florida, United States
Medical Research Center of Connecticut, LLC
🇺🇸Hamden, Connecticut, United States
TrialSpark, Inc.
🇺🇸Washington, District of Columbia, United States
American Research Institute, Inc
🇺🇸Cutler Bay, Florida, United States
Top Medical Research
🇺🇸Cutler Bay, Florida, United States
Nature Coast Clinical Research
🇺🇸Inverness, Florida, United States
Cfagi Llc
🇺🇸Maitland, Florida, United States
Sensible Healthcare
🇺🇸Ocoee, Florida, United States
Gulf Region Clinical Research Institute
🇺🇸Pensacola, Florida, United States
Infinite Clinical Trials
🇺🇸Riverdale, Georgia, United States
Summit Clinical Research, LLC
🇺🇸Carnesville, Georgia, United States
University of Iowa Hospitals and Clinics
🇺🇸Iowa City, Iowa, United States
MediSphere Medical Research Center, LLC
🇺🇸Evansville, Indiana, United States
Cronola LLC
🇺🇸Houma, Louisiana, United States
Delta Research Partners
🇺🇸Bastrop, Louisiana, United States
New Orleans Research Institute - Metropolitan Gastroenterology Associates
🇺🇸Metairie, Louisiana, United States
Gastro Center of Maryland
🇺🇸Columbia, Maryland, United States
Frederick Gastroenterology Associates, PA an Elligo Health Research Site
🇺🇸Frederick, Maryland, United States
Vida Clinical Studies
🇺🇸Dearborn, Michigan, United States
Boston VA Healthcare System
🇺🇸West Roxbury, Massachusetts, United States
National Clinical, LLC
🇺🇸Hamtramck, Michigan, United States
Henry Ford Health System
🇺🇸Novi, Michigan, United States
Gastroenterology Associates of Western Michigan
🇺🇸Wyoming, Michigan, United States
Synexus Clinical Research
🇺🇸Greer, South Carolina, United States
Garden State Endocrinology
🇺🇸Brick, New Jersey, United States
CHEAR Center, LLC
🇺🇸Bronx, New York, United States
AGA Clinical Research Associates LLC
🇺🇸Egg Harbor Township, New Jersey, United States
United Health Services Hospitals, Inc.
🇺🇸Johnson City, New York, United States
Carolinas Healthcare-Charlotte
🇺🇸Charlotte, North Carolina, United States
Carolina Digestive Health Associates
🇺🇸Concord, North Carolina, United States
Cumberland Research Associates, LLC
🇺🇸Fayetteville, North Carolina, United States
PMG Research Salisbury
🇺🇸Salisbury, North Carolina, United States
Triad Clinical Trials
🇺🇸Greensboro, North Carolina, United States
Hometown Urgent Care and Research
🇺🇸Columbus, Ohio, United States
Dayton Gastroenterology,Inc.
🇺🇸Beavercreek, Ohio, United States
Premier Clinical Research d.b.a. STAT Research
🇺🇸Franklin, Ohio, United States
Family Practice Center of Wadsworth, Inc.
🇺🇸Wadsworth, Ohio, United States
Digestive Disease Specialists Inc
🇺🇸Oklahoma City, Oklahoma, United States
Family Medical Associates, Research Department
🇺🇸Levittown, Pennsylvania, United States
Montgomery Medical, Inc.
🇺🇸Smithfield, Pennsylvania, United States
Carolina Medical Research
🇺🇸Clinton, South Carolina, United States
Gastroenterology Associates, PA
🇺🇸Greenville, South Carolina, United States
Advanced Research Institute, Inc.
🇺🇸Ogden, Utah, United States
Nepean Hospital
🇦🇺Kingswood, New South Wales, Australia
Cardinal Internal Medicine
🇺🇸Woodbridge, Virginia, United States
The Alfred Hospital
🇦🇺Melbourne, Victoria, Australia
UMHAT - Kaspela- EOOD
🇧🇬Plovdiv, Bulgaria
Royal Melbourne Hospital
🇦🇺Parkville, Victoria, Australia
MHAT Yuliya Vrevska Byala
🇧🇬Byala, Ruse, Bulgaria
Alexandrovska University Hospital
🇧🇬Sofia, Bulgaria
Medical Center Asklepion - Humane Medicine Research EOOD
🇧🇬Sofia, Bulgaria
CHU Nantes
🇫🇷Nantes Cedex 1, France
Kumudini Devi Diabetes Research Center; Ramdevrao Hospital
🇮🇳Hyderabad, Andhra Pradesh, India
Hopital Charles Nicolle
🇫🇷Rouen Cedex, France
King George Hospital
🇮🇳Visakhapatnam, Andhra Pradesh, India
Dr. Jivraj Mehta Smarak Health Foundation Bakeri Medical Research Centre - Gasterentrology
🇮🇳Ahmedabad, Gujarat, India
Victoria Hospital
🇮🇳Bangalore, Karnataka, India
Life Care Hospital & Research Centre
🇮🇳Bangalore, Karnataka, India
Diacon Hospital and research Center - Diabetology
🇮🇳Bengaluru, Karnataka, India
Rajalakshmi Hospital
🇮🇳Bengaluru, Karnataka, India
Vinaya Hospital & Research Centre
🇮🇳Mangalore, Karnataka, India
M V Hospital & Research Centre
🇮🇳Lucknow, Uttar Pradesh, India
Arthur Asirvatham Hospital
🇮🇳Madurai, India
Sir Ganga Ram Hospital
🇮🇳New Delhi, India
Bnai Zion Medical Center
🇮🇱Haifa, Israel
E. Wolfson Medical Center
🇮🇱Holon, Israel
Digestive Diseases Institute
🇮🇱Jerusalem, Israel
Gastroenterology Institute
🇮🇱Tel Aviv, Israel
Chonbuk National University Hospital
🇰🇷Jeonju, Jeollabuk-Do, Korea, Republic of
Sanggye Paik Hospital, Inje University College of Medicine
🇰🇷Seoul, Nowon-gu, Korea, Republic of
Endocrinology & Diabetes Center
🇮🇱Safed, Israel
Hospital Sultanah Bahiyah
🇲🇾Alor Setar, Kedah, Malaysia
University Malaya Medical Centre
🇲🇾Kuala Lumpur, Malaysia
Hospital Taiping
🇲🇾Taiping, Malaysia
Universiti Sains Malaysia
🇲🇾Kubang Kerian, Malaysia
Manila Doctors Hospital
🇵🇭Ermita, Manila, Philippines
San Juan De Dios Educational Foundation, Inc.
🇵🇭Pasay, Metro Manila, Philippines
Perpetual Succor Hospital
🇵🇭Cebu City, Philippines
Cardinal Santos Medical Center
🇵🇭San Juan City, Metro Manila, Philippines
Ospital ng Makati
🇵🇭Makati City, NCR, Philippines
West Visayas State University Medical Center
🇵🇭IloIlo City, Philippines
St. Luke's Medical Center
🇵🇭Quezon City, Philippines
Synexus Polska Sp.z o.o.
🇵🇱Pomorskie, Gdansk, Poland
Endoskopia Sp. Z O.O.
🇵🇱Sopot, Pomorskie, Poland
CenterMed Krakow Ltd
🇵🇱Krakow, Malopolska, Poland
Centrum Medyczne Pratia S.A. Warsaw, Poland
🇵🇱Warsaw, Mazowian, Poland
Wojewodzki Szpital Specjalistyczny w Olsztynie
🇵🇱Olsztyn, Warmia-Mazury, Poland
NZOZ Vita Diabetica - Malgorzata Buraczyk
🇵🇱Bialystok, Poland
Centrum Medyczne Lukamed
🇵🇱Chojnice, Poland
Specjalistyczny Gabinet Neurologiczny Marta Banach
🇵🇱Kraków, Poland
Synexus Polska Sp. z o.o. Oddzial w Warszawie
🇵🇱Warszawa, Poland
Centrum Badan Klinicznych Piotr Napora Lekarze Spolka Partnerska
🇵🇱Wroclaw, Poland
DRS Wroclaw
🇵🇱Wroclaw, Poland
National University Hospital
🇸🇬Singapore, Singapore
Changi General Hospital
🇸🇬Singapore, Singapore
Hospital Universitario Principe de Asturias
🇪🇸Madrid, Spain
Singapore General Hospital
🇸🇬Singapore, Singapore
Maharaj Nakorn Chiang Mai Hospital
🇹🇭Chiang Mai, Thailand
Hospital Universitario De Salamanca
🇪🇸Salamanca, Spain
Hospital Universitario Virgen del Rocío
🇪🇸Sevilla, Spain
Phramongkutklao Hospital
🇹🇭Bangkok, Thailand
Faculty of Medicine, Siriraj Hospital, Mahidol University
🇹🇭Bangkok, Thailand
Limited Liability Company "Medical Center "Salutem"
🇺🇦Vinnitsa, Vinnyts'ka Oblast', Ukraine
Communal Institution "Odesa Regional Clinical Hospital", Out-patient department
🇺🇦Odesa, Odesa Region, Ukraine
Municipal Institution City Hospital No. 7
🇺🇦Zaporizhzhia, Zaporizhzhia Region, Ukraine
Regional municipal institution "Chernivtsi's regional clinical hospital", gastroenterological department, Higher state educational establishment of Ukraine "Bukovinian state medical university", department of internal medicine and infectious diseases, c.C
🇺🇦Chernivtsi, Ukraine
Regional Public Organization Chernivtsi Regional Endocrinology Center
🇺🇦Chernivtsi, Ukraine
Ivano-Frankivsk Central City Clinical Hospital
🇺🇦Ivano-Frankivsk, Ukraine
Municipal nonprofit entity of Kharkiv municipal council
🇺🇦Kharkiv, Ukraine
State Institution Ukrainian State Research Institute of Medical and Social Problems of Disability of the Ministry of Health of Ukraine
🇺🇦Dnipro, Ukraine
Ivano-Frankivsk National Medical University
🇺🇦Ivano-Frankivsk, Ukraine
AS PVNZ
🇺🇦Kyiv, Ukraine
Kyiv municipal clinical endocrinological center
🇺🇦Kyiv, Ukraine
L.T.Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine
🇺🇦Kharkiv, Ukraine
Clinical Endocrinology of SI "V.Danilevsky Institute for endocrine pathology problems National Academy of Medical sciences of Ukraine"
🇺🇦Kharkiv, Ukraine
Communal Institution Kherson City Clinical Hospital
🇺🇦Kherson, Ukraine
Medical Center Universal Clinic Oberig
🇺🇦Kyiv, Ukraine
AS Medbud Clinic
🇺🇦Kyiv, Ukraine
Limited Liability Company "Medical and Diagnostic Center "ADONIS Plus", outpatient department, c. Kyiv
🇺🇦Kyiv, Ukraine
Polyclinic of medical services and rehabilitation department of State Joint-Stock Holding Company Artem, day-patient unit
🇺🇦Kyiv, Ukraine
Odessa Railway Clinical Hospital of Branch of HC JSC Ukrzaliznytsia, Odessa National Medical University
🇺🇦Odesa, Ukraine
Poltava Regional Clinical Hospital
🇺🇦Poltava, Ukraine
Ternopil University Hospital
🇺🇦Ternopil, Ukraine
6th City Clinical Hospital, c. Zaporizhzhia
🇺🇦Zaporizhzhia, Ukraine
Municipal nonprofit entity "Vinnytsia's city clinical hospital #1", c. Vinnytsia
🇺🇦Vinnytsia, Ukraine
Peak Gastroenterology Associates
🇺🇸Colorado Springs, Colorado, United States
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
University of North Carolina at Chapel Hill
🇺🇸Chapel Hill, North Carolina, United States
Synexus Polska Sp. z o.o.Oddzial w Poznaniu
🇵🇱Poznan, Poznañ, Poland
Synexus Polska sp.z.o.o oddzial Czestochowa
🇵🇱Czestochowa, Poland
Central Arizona Medical Associates
🇺🇸Mesa, Arizona, United States
Soroka University Medical Center
🇮🇱Beer Sheba, Israel
Synexus Polska Sp. z o.o. Oddzial w Lodzi
🇵🇱Lodz, Poland
Sanitas Centrum Medyczne
🇵🇱Lublin, Poland
Kyiv Railway hospital on the railway transport #2 of the branch "health
🇺🇦Kyiv, Ukraine
Arkansas Gastorenterology
🇺🇸North Little Rock, Arkansas, United States
Private Small-Scale Enterprise Medical Centre Pulse
🇺🇦Vinnytsia, Ukraine
Avant Research Associates,LLC
🇺🇸Austin, Texas, United States
Kovai Diabetes Speciality Centre
🇮🇳Coimbatore, Tamil Nadu, India
University of Kansas Medical Center
🇺🇸Kansas City, Kansas, United States