NCT01609075已完成不适用
Use of Bevacizumab in the Treatment of Metastatic Colorectal Cancer (mCRC) in Italy: an Observational Cohort Study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 437
- 主要终点
- Proportion of patients with Avastin treatment discontinuation due to either disease progression or Avastin-related adverse events
研究概览
简要总结
This observational, multicenter, retrospective/prospective study will evaluate the use of Avastin (bevacizumab) in clinical practice in patients with metastatic colorectal cancer. Patients having initiated first-line treatment with a fluoropyrimidine-based chemotherapy and Avastin will be followed for up to 15 months.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients, >/= 18 years of age
- •Metastatic colorectal cancer
- •Having initiated first-line treatment with fluoropyrimidine-based chemotherapy plus Avastin between
- •September 2011 and
- •February 2012
- •Availability of test fro K-RAS genotyping
排除标准
- •Participation in a clinical trial during treatment with Avastin
结局指标
主要结局
Proportion of patients with Avastin treatment discontinuation due to either disease progression or Avastin-related adverse events
时间窗: approximately 15 months
次要结局
- Progression-free survival (patients with treatment discontinuation due to disease progression or Avastin-related toxicity as compared to patients with treatment discontinuation due to other causes)(approximately 15 months)
- Proportion of patients with treatment discontinuation due to other causes(approximately 15 months)
- Incidence of other causes for treatment discontinuation(approximately 15 months)
- Second-line treatments initiated(approximately 15 months)
研究者
相似试验
已完成
不适用
A Study of Avastin With Chemotherapy for Treatment of Metastatic or Advanced and Unresectable Colorectal AdenocarcinomaColorectal CancerNCT00097578Genentech, Inc.1,953
已完成
不适用
A Study of Avastin in Combination With Chemotherapy for Treatment of Colorectal Cancer and Non-Small Cell Lung Cancer (ARIES)Colorectal CancerNon-Small Cell Lung CancerNCT00388206Genentech, Inc.3,998
已完成
3 期
A Study of Bevacizumab (Avastin) in Combination With Chemotherapy in Participants With Metastatic Cancer of the Colon or Rectum.Colorectal CancerNCT01169558Hoffmann-La Roche168
已完成
2 期
Neoadjuvant Clinical Trial to Evaluate the Efficacy of Bevacizumab for Renal Cell CarcinomaKidney CancerRenal Cell CarcinomaNCT00113217M.D. Anderson Cancer Center52
已完成
不适用
A Study to Evaluate Safety and Effectiveness of Bevacizumab in Combination With Paclitaxel and Cisplatin/Carboplatin or Toptecan in Participants With Advanced Cervical CancerCervical CancerNCT03071848Hoffmann-La Roche84