NCT00034567已完成不适用
Alzheimer's Disease Prevention Instrument Protocol
National Institute on Aging (NIA)39 个研究点 分布在 1 个国家目标入组 650 人开始时间: 2002年5月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 650
- 试验地点
- 39
研究概览
简要总结
This project will focus on the development and testing of efficient, cost effective measures that are specifically designed for use in Alzheimer's Disease (AD) primary prevention trials.
详细描述
This project will focus on the development and testing of efficient, cost effective measures that are specifically designed for use in AD primary prevention trials. The new or improved measures that have been developed will then be evaluated in 650 nondemented subjects enrolled in a simulated Alzheimer's disease prevention trial. Once enrolled, subjects will be followed for four years with annual clinical evaluations and interim six-month phone calls.
研究设计
- 研究类型
- Observational
- 观察模型
- Defined Population
- 时间视角
- Prospective
入排标准
- 年龄范围
- 75 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •75 years or older.
- •Fluent in English or Spanish.
- •Stable medical condition for four weeks prior to screening visit.
- •Stable medications for four weeks prior to screening visit.
- •Either cognitively normal, or mild cognitive impairment. If MCI, the subject's CDR at screening have a global score of 0.
- •mMMSE score greater than 88 for subjects with at least 8 years education, or greater than 80 for subjects with less than 8 years education, and FCSRT total free plus cued recall score greater than 44 with 3 learning trials.
- •Willing to participate in four to five year follow-up study.
- •Willing to identify person who can serve as informant.
- •At least six years education or work history sufficient to exclude mental retardation
排除标准
- •Meets DSM IV criteria for dementia
- •History of clinically significant medical illness that would interfere with participation in trial, including active malignancy, myocardial infarction, or cerebrovascular accident within the past year
- •Alcohol or substance abuse and/or active major psychiatric disorders
- •Concurrent participation in a clinical drug trial
- •History of mental retardation
研究者
研究点 (39)
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