Circumferential Section Pane Less Than 1 mm in Esophagectomy for Esophageal Cancer.

• Conditions: Esophageal Cancer

• Registration Number: NCT01959906
• Lead Sponsor: University Hospital, Gasthuisberg

Brief Summary

A suspicious circumferential resection margin (CRM), defined as tumor cells within 1 mm of the CRM, is still controversial. The aim of this study was to compare the clinical significance of a suspicious CRM to histologically positive (R1) and negative margin (R0) resections in patients with pT3 esophageal and GE-Junction tumors.

Detailed Description

From our prospectively build database 923 consecutive pT3 patients operated between january 1990 and june 2013 were selected. CRM status in patients treated by surgery only (n = 747) or after neoadjuvant therapy (n = 176) was recorded prospectively after surgery.

Kaplan-Meier survival curves were generated, and factors affecting survival were assessed by Cox regression multivariate analysis.

Study Timeline

• Study Start: 2013-07
• Status Verified: 2013-10
• Study First Submitted: 2013-10-08
• Study First Submitted QC: 2013-10-09
• Last Update Submitted: 2013-10-09
• Study First Posted: 2013-10-10
• Last Update Posted: 2013-10-10
• Primary Completion: 2013-12
• Study Completion: 2014-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 923

Inclusion Criteria

• pathologic T3 tumours of esophagus or GEJ

Exclusion Criteria

• pT other than pT3
• R2 resections

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
overall survival	5 years after esophagectomy	5 years overall survival after esophagectomy

Trial Locations

Locations (1)

University Hospital Leuven; 🇧🇪 Leuven, Belgium