Effect of Carum Carvi on Thyroid Hormones and TSH Level
Phase 1
- Conditions
- Thyroid Cancer Patients
- Interventions
- Drug: PlaceboDrug: Carum Cravi
- Registration Number
- NCT01471288
- Lead Sponsor
- Mashhad University of Medical Sciences
- Brief Summary
Carum Carvi has been frequently used in traditional medicine for a variety of disease ranging from dyspepsia to Alzheimer's disease.We observed high TSH levels in few patients with thyroid cancer who receiving Carum Carvi despite being on suppressive dose of levothyroxin. TSH level returned to normal after discontinuation of the Carum carvi. This observation led to a pilot study for evaluation of the effect of carum carvi on thyroid function.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- Age 18-65
- Hypothyroid patients under treatment with levothyroxin
- Normal euthyroid patients with no goiter
Exclusion Criteria
- Pregnancy or lactation
- Severe lung or gasterointestinal disease
- Heart failure or renal failure
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Group2 Placebo Hypothyroid patients taking levothyroxin Group3 Carum Cravi Normal controls Group4 Placebo Normal controls Group 1 Carum Cravi Hypothyroid patients taking levothyroxin.
- Primary Outcome Measures
Name Time Method Change of Thyroid and thyrotropin values from baseline at 2 and 6 weeks 0-2-6 Weeks TSH, Free T4, Free T3, T4RIA and T3RIA
- Secondary Outcome Measures
Name Time Method Change of hypothyroidism index from baseline at 2 and 6 weeks 0,2 and 6 weeks Hypothyroidism Index
Trial Locations
- Locations (1)
Nuclear Medicine Department, Ghaem Hospital
🇮🇷Mashhad, Iran, Islamic Republic of