Pupillometry Guided Versus Standard Practice Remifentanil Administration and Total Opioid Consumption
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 65
- 试验地点
- 1
- 主要终点
- peroperative remifentanil consumption in µg/kg/min
研究概览
简要总结
The aim of this prospective randomized study was to evaluate the impact of peroperative pupillometry monitoring on per and post-operative opioid consumption in major gynecological surgery. All patients were anesthetized with TCI of propofol and remifentanil. In the intervention group, peroperative remifentanil target was guided by pupillometry. In the other group, remifentanil was administered according to standard practice.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Elective gynecological surgery
- •No ophtalmologic or neurologic disease
- •No chronic analgesic medication
- •Expected length of surgery 60 minutes minimum
排除标准
- •ophtalmologic or neurologic disease
- •chronic analgesic medication
研究组 & 干预措施
PUPILLO
Videopupillometer Algiscan peroperative remifentanil target concentration adapted every five minutes to pupillary diameter in patients under propofol and remifentanil TCI
干预措施: Propofol (Drug)
PUPILLO
Videopupillometer Algiscan peroperative remifentanil target concentration adapted every five minutes to pupillary diameter in patients under propofol and remifentanil TCI
干预措施: Videopupillometer Algiscan (Device)
PUPILLO
Videopupillometer Algiscan peroperative remifentanil target concentration adapted every five minutes to pupillary diameter in patients under propofol and remifentanil TCI
干预措施: Remifentanil (Drug)
STANDARD
peroperative remifentanil target concentration as standard practice in patients under propofol and remifentanil TCI
干预措施: Standard practice (Other)
STANDARD
peroperative remifentanil target concentration as standard practice in patients under propofol and remifentanil TCI
干预措施: Propofol (Drug)
STANDARD
peroperative remifentanil target concentration as standard practice in patients under propofol and remifentanil TCI
干预措施: Remifentanil (Drug)
结局指标
主要结局
peroperative remifentanil consumption in µg/kg/min
时间窗: duration of surgery
次要结局
- peroperative propofol consumption in mg/kg/h(duration of surgery)
- post-operative morphine requirements in mg/kg(24 hours)
研究者
Pr Isabelle CONSTANT
Professor Isabelle Constant
Hôpital Armand Trousseau