Vitamin D Supplementation in Healthy Adults in Prolonged Endurance Exercise
- Conditions
- Healthy
- Registration Number
- NCT05781620
- Lead Sponsor
- Taipei Medical University
- Brief Summary
The purpose of this study is to investigate the effects of vitamin D supplementation on biochemistry response and skeletal muscle synthesis in prolonged endurance exercise.
- Detailed Description
Endurance exercise mode will be used to evaluate the effects of vitamin D supplementation on cardiac biomarkers, metabolic hormones, oxidative damage, and inflammation responses. An independent samples and dose titration design will be used to assign 30 participants to the experimental group (n = 15) or placebo group (n = 15). All participants in the experimental group will have serum 25(OH)D concentrations higher than 48 ng/mL after supplementation period. After the prolonged endurance exercise test, the blood samples will be collected for analyzing biomarkers. Data will be analyzed by Two-way mixed design ANOVA.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 50
Not provided
-
The volunteers were excluded if they have the situation stated below:
- history of cardiovascular, liver, kidney and diabetes disease
- acute sport injury
- their concentration of 25(OH)D is over 30 ng/mL, or maximal oxygen consumption is under 40 ml/kg/mint
- participated in any clinical trials or experimental research in the last 3 months before our experiment
- taking supplement during the experimental period
- did not maintain their regular eating habit or drink alcohol
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Concentration of Catalase 24-hour after exercise Concentration of CK-MB 24-hour after exercise Concentration of Testosterone 24-hour after exercise Concentration of Cortisol 24-hour after exercise Concentration of SOD 24-hour after exercise Concentration of eosinophil 24-hour after exercise Concentration of cTnI 24-hour after exercise Concentration of IL-15 24-hour after exercise Concentration of lymphocyte 24-hour after exercise Concentration of CD8+ 24-hour after exercise Concentration of IL-10 24-hour after exercise Concentration of CD56+ 24-hour after exercise Concentration of NT-proBNP 24-hour after exercise Concentration of CK 24-hour after exercise Concentration of β-endorphin 24-hour after exercise Concentration of Growth hormone 24-hour after exercise Concentration of IGF-1 24-hour after exercise Concentration of TBARS 24-hour after exercise Concentration of PC 24-hour after exercise Concentration of TNF-α 24-hour after exercise Concentration of IL-8 24-hour after exercise Concentration of LDH 24-hour after exercise Concentration of IL-6 24-hour after exercise Concentration of basophil 24-hour after exercise Concentration of monocyte 24-hour after exercise Concentration of leukocyte 24-hour after exercise Concentration of neutrophil 24-hour after exercise Concentration of CD19+ 24-hour after exercise Concentration of CD4+ 24-hour after exercise
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Taipei Medical University
🇨🇳Taipei, Taiwan
Taipei Medical University🇨🇳Taipei, Taiwan