Effects of Vitamin D Supplementation on Biochemical Reaction and Skeletal Muscle Synthesis in Prolonged Endurance Exercise and Cluster Set Configurations of Resistance Training
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Concentration of lymphocyte
研究概览
简要总结
The purpose of this study is to investigate the effects of vitamin D supplementation on biochemistry response and skeletal muscle synthesis in prolonged endurance exercise.
详细描述
Endurance exercise mode will be used to evaluate the effects of vitamin D supplementation on cardiac biomarkers, metabolic hormones, oxidative damage, and inflammation responses. An independent samples and dose titration design will be used to assign 30 participants to the experimental group (n = 15) or placebo group (n = 15). All participants in the experimental group will have serum 25(OH)D concentrations higher than 48 ng/mL after supplementation period. After the prolonged endurance exercise test, the blood samples will be collected for analyzing biomarkers. Data will be analyzed by Two-way mixed design ANOVA.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
盲法说明
A double-blind, matched-pair study design
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •The volunteers were excluded if they have the situation stated below:
- •history of cardiovascular, liver, kidney and diabetes disease
- •acute sport injury
- •their concentration of 25(OH)D is over 30 ng/mL, or maximal oxygen consumption is under 40 ml/kg/mint
- •participated in any clinical trials or experimental research in the last 3 months before our experiment
- •taking supplement during the experimental period
- •did not maintain their regular eating habit or drink alcohol
结局指标
主要结局
Concentration of lymphocyte
时间窗: 24-hour after exercise
Concentration of CD8+
时间窗: 24-hour after exercise
Concentration of Catalase
时间窗: 24-hour after exercise
Concentration of CK-MB
时间窗: 24-hour after exercise
Concentration of Testosterone
时间窗: 24-hour after exercise
Concentration of Cortisol
时间窗: 24-hour after exercise
Concentration of SOD
时间窗: 24-hour after exercise
Concentration of eosinophil
时间窗: 24-hour after exercise
Concentration of cTnI
时间窗: 24-hour after exercise
Concentration of IL-15
时间窗: 24-hour after exercise
Concentration of IL-10
时间窗: 24-hour after exercise
Concentration of CD4+
时间窗: 24-hour after exercise
Concentration of CD56+
时间窗: 24-hour after exercise
Concentration of NT-proBNP
时间窗: 24-hour after exercise
Concentration of CK
时间窗: 24-hour after exercise
Concentration of β-endorphin
时间窗: 24-hour after exercise
Concentration of Growth hormone
时间窗: 24-hour after exercise
Concentration of IGF-1
时间窗: 24-hour after exercise
Concentration of TBARS
时间窗: 24-hour after exercise
Concentration of PC
时间窗: 24-hour after exercise
Concentration of TNF-α
时间窗: 24-hour after exercise
Concentration of IL-8
时间窗: 24-hour after exercise
Concentration of LDH
时间窗: 24-hour after exercise
Concentration of IL-6
时间窗: 24-hour after exercise
Concentration of basophil
时间窗: 24-hour after exercise
Concentration of monocyte
时间窗: 24-hour after exercise
Concentration of leukocyte
时间窗: 24-hour after exercise
Concentration of neutrophil
时间窗: 24-hour after exercise
Concentration of CD19+
时间窗: 24-hour after exercise
次要结局
未报告次要终点