Clinical and mechanistic study of electroacupuncture modulation of cortical GABA receptor function in patients with moderate depression with insomnia disorder
- Conditions
- Depressive disorders and insomnia
- Registration Number
- ITMCTR2200006784
- Lead Sponsor
- Bao'an Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
1. DSM-5 diagnostic criteria for depression with insomnia disorder of mental disorders in the United States
2. The 17 item score of Hamilton Depression Scale (HAMD): 24= score > 17
3. The Pittsburgh Sleep Quality Index Scale(PSQI):score=7
4. Age 18-65,No gender limit;
5. Right handedness,Education level above elementary school;
6. Those with a disease duration = 2 weeks, = 2 years, who have not received medication, physical or psychological therapy within the last 3 weeks, or those with stable disease, whose original medication regimen has been maintained for at least 3 weeks;
7. Signed informed consent to voluntarily participate in this study.
1.Past and current self-inflicted suicidal plans or behaviors, psychotic symptoms;
2.Previous diagnosis of schizophrenia, bipolar disorder or other mental disorder-like illness;
3.History of significant personality disorder;
4.History of alcohol or substance abuse;
5.Previous history of traumatic brain injury, epilepsy;
6.Liver and kidney insufficiency, metal implants or major diseases of the cardiovascular system;
7.Those who may have poor compliance or fear of acupuncture;
8.Left handedness;
9.Pregnant, pregnant and lactating women.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method AIS;RMT\MEPs\CSP\LICI\SICI\ICF\SAT;PSQI;
- Secondary Outcome Measures
Name Time Method HAMD-17;SCL-90;