Aberrant Myeloid Lineage Differentiation in HIV/AIDS Patients

Completed

• Conditions: Leukemia; HIV Infections

• Registration Number: NCT05808803
• Lead Sponsor: Zhongnan Hospital

Brief Summary

The investigators included 782 HIV-infected patients from January 2016 to October 2020 Zhongnan Hospital of Wuhan University, whose AIDS diagnosis criteria met the "AIDS Diagnosis and Treatment Guide (2018 edition)" of Chinese Medical Association.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-01-01
• Primary Completion: 2020-10-31
• Study Completion: 2022-01-31
• Status Verified: 2023-01
• Study First Submitted: 2023-02-10
• Study First Submitted QC: 2023-04-10
• Study First Posted: 2023-04-11
• Last Update Submitted: 2023-09-26
• Last Update Posted: 2023-09-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 782

Inclusion Criteria

• HIV-infection

Exclusion Criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The proportion of granulocytes and granulocyte/macrophage progenitors in myelogram of HIV/AIDS patients	2020	Flow cytometric immunophenotyping of an EDTA-anticoagulated BM aspirate specimen was performed. A standard BM assay with erythrocyte cell lysis was used for all BM aspirate specimens. Flow cytometric analysis was conducted using a FACS Canto II flow cytometer (Becton Dickinson, Sunnyvale, CA, USA).

Secondary Outcome Measures

Name	Time	Method
Neutrophil counts in peripheral blood of HIV/AIDS patients	2020	Blood samples were drawn from patients undergoing routine diagnostic blood analysis at our institute by sterile venipuncture into tubes containing 5.4 mg of K2EDTA and analyzed by the automated hematology analyzer.