comparison of topiramate and sodium valporate in migraine prophylaxis

Phase 2

• Conditions: Condition 1: Common migraine. Condition 2: Classical migraine.; Migraine without aura [common migraine]; Migraine with aura [classical migraine]

• Registration Number: IRCT138802171856N1
• Lead Sponsor: Vice-chancellor for research, Kermanshah University of Medical Sciences and Health Services

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 56

Inclusion Criteria

more than 4 and less than 10 attacks monthly, patient age at onset of headache less than 50 years, patient’s age between 18-65 years, discontinuation of other prophylactic drugs one month prior to study, interval between attacks more than 48 hours
Exclusion criteria: pregnancy and breast feeding, non-migraine headaches, overuse of medications in migraine attacks (consumption of NSAID, Ergots & Triptans more than 8 days a month), substance and alcohol abuse, illiteracy of patients and their family (unable to fill diaries)

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Severity of headache. Timepoint: in each migraine attack. Method of measurement: patient will record the headache severity in daily notes as VAS (from 1 to 10) & physician registers them every 4 weeks.;Duration of migraine attack. Timepoint: in each migraine attack. Method of measurement: patient records the hours of headache in each attack , physician register them every 4 weeks.;Headache frequency. Timepoint: every 4 week. Method of measurement: According to patients daily notes.;Analgesic use. Timepoint: every 4 week. Method of measurement: According to patients daily notes.

Secondary Outcome Measures

Name	Time	Method
Clinical side effects. Timepoint: every 4 weeks. Method of measurement: According to patients daily notes.;Blood cell count & liver function test changes. Timepoint: before and at the end of treatment course. Method of measurement: lab tests.