Enoxaparin in treatment of lichen planus
Not Applicable
- Conditions
- lichen planus.lichen planus tropicus
- Registration Number
- IRCT2012122211841N1
- Lead Sponsor
- Vice chancellor for Administrative and Financial of Medical School
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 46
Inclusion Criteria
patients with disseminated lichen planus at least 6 months represent to the clinic. Exclusion criteria: 1. Contraindications of heparin and its derivatives, including: hemostasis, acquired or congenital disorder, the risk of bleeding caused by uncontrolled hypertension, active peptic ulcer, recent cerebrovascular accident, sensitivity to enoxaparin or heparin derivatives; 2. Chronic liver disease; 3. Hepatitis B and C; 4. Contraindications for taking oral prednisone; 5. Medications that are known to lead to the LP like reaction; 6. Lichen planus of nails; 7. Scalp involvement; 8. Ulcerated mucosal lesions; 9. Heparin therapy complications such as drug sensitivity, acute bleeding.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pruritus. Timepoint: befor treatment-weekly in treatment period- in 1,3 and 6 months following end of treatment. Method of measurement: visual analogue scale(VAS).;Extention of active lesions. Timepoint: befor treatment-weekly in treatment period- in 1,3 and 6 months following end of treatment. Method of measurement: percentage of skin surface.
- Secondary Outcome Measures
Name Time Method Bleeding. Timepoint: weekly in period of treatment. Method of measurement: Observation (yes or no).;Hypersensitivity. Timepoint: weekly in period of treatment. Method of measurement: Observation (yes or no).