Changes in the Permeability of the Blood Brain Barrier and Intestinal Barrier in Humans During Conditions of Stress and Immune Activation: in Vivo Studies

Completed

• Conditions: Combat Training Stress

• Registration Number: NCT01417416
• Lead Sponsor: National University Hospital, Singapore

Brief Summary

The relevance of BBB and IB permeability changes as a major precipitating cause for cognitive and digestive dysfunction in the military stress setting.

Detailed Description

Not available

Study Timeline

• Status Verified: 2009-02
• Study First Submitted: 2011-08-15
• Study First Submitted QC: 2011-08-15
• Last Update Submitted: 2011-08-15
• Study First Posted: 2011-08-16
• Last Update Posted: 2011-08-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: Not specified

Inclusion Criteria

• Healthy male troops (aged 18-50 yrs) scheduled to be engaged in a protracted multi-day stressful field exercises.

Exclusion Criteria

• Significantly systemic disease, including cardiovascular, psychiatric, neurological (including polyneuropathies) and endocrine disease including diabetes mellitus.
• No written informed consent obtained from subject.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified