Neuro-ophthalmology and Autoimmune Encephalitis (NODE)

Completed

• Conditions: Autoimmune Encephalitis
• Interventions: Other: oculomotor movement recordings, neurovisual assessment

• Registration Number: NCT03872284
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Autoimmune encephalitis represents a group of rare and heterogeneous neurological disorders. Pathophysiological mechanisms in these diseases are still unknown. Recently, oculomotor and neurovisual disorders have been described. Cerebral areas and neuronal networks associated with these abnormalities are well described. The investigator proposes to study and describe such neuro-ophthalmological disorders in a prospective cohort of patients with a autoimmune encephalitis, to better understand the pathophysiological basis of this neurological condition.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-03-11
• Study First Submitted QC: 2019-03-11
• Study First Posted: 2019-03-13
• Study Start: 2020-01-22
• Primary Completion: 2020-02-26
• Study Completion: 2020-02-26
• Status Verified: 2025-01
• Last Update Submitted: 2025-01-09
• Last Update Posted: 2025-01-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 2

Inclusion Criteria

• Diagnosis of autoimmune encephalitis
• With or without pathological antibody
• Aged from 18 to 70 years old
• Able to understand the aims and methods of this project
• Non opposed to the participation of this study

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Exclusion Criteria

• Other neurological, psychiatric or systemic conditions, which could induce neuro-ophthalmological signs Cognitive impairment, which is not linked to autoimmune encephalitis
• Ophthalmological condition, which could modify the interpretation of neuro-ophthalmological data Inability to remain seated
• Pregnancy or breast feeding
• Adults under guardianship

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
1	oculomotor movement recordings, neurovisual assessment	Patients in the study group have a diagnosis of autoimmune encephalitis, are 18 to 70 years old, and have no significant comorbidity such as psychiatric, neurological conditions and able to understand the aim of this study.

Primary Outcome Measures

Name	Time	Method
Percentage of patients presenting a neuro-ophthalmological abnormality.	Day 0	A neuro-ophthalmological disorder is defined as an abnormality in the oculo-motor movement recording or/and the presence of a neurovisual impairment.
Percentage of patients presenting neuro-ophthalmological abnormality.	At 6 months if an abnormality is found	A neuro-ophthalmological disorder is defined as an abnormality in the oculo-motor movement recording or/and the presence of a neurovisual impairment.

Trial Locations

Locations (1)

Hospices Civils de Lyon; 🇫🇷 Bron, France