Study of Neuro-ophthalmology Disorders in Autoimmune Encephalitis (NODE)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 2
- 试验地点
- 1
- 主要终点
- Percentage of patients presenting a neuro-ophthalmological abnormality.
研究概览
简要总结
Autoimmune encephalitis represents a group of rare and heterogeneous neurological disorders. Pathophysiological mechanisms in these diseases are still unknown. Recently, oculomotor and neurovisual disorders have been described. Cerebral areas and neuronal networks associated with these abnormalities are well described. The investigator proposes to study and describe such neuro-ophthalmological disorders in a prospective cohort of patients with a autoimmune encephalitis, to better understand the pathophysiological basis of this neurological condition.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of autoimmune encephalitis
- •With or without pathological antibody
- •Aged from 18 to 70 years old
- •Able to understand the aims and methods of this project
- •Non opposed to the participation of this study
排除标准
- •Other neurological, psychiatric or systemic conditions, which could induce neuro-ophthalmological signs Cognitive impairment, which is not linked to autoimmune encephalitis
- •Ophthalmological condition, which could modify the interpretation of neuro-ophthalmological data Inability to remain seated
- •Pregnancy or breast feeding
- •Adults under guardianship
结局指标
主要结局
Percentage of patients presenting a neuro-ophthalmological abnormality.
时间窗: Day 0
A neuro-ophthalmological disorder is defined as an abnormality in the oculo-motor movement recording or/and the presence of a neurovisual impairment.
Percentage of patients presenting neuro-ophthalmological abnormality.
时间窗: At 6 months if an abnormality is found
A neuro-ophthalmological disorder is defined as an abnormality in the oculo-motor movement recording or/and the presence of a neurovisual impairment.
次要结局
未报告次要终点