The use of oxygen-hydrogen mixture as an antioxidant
- Conditions
- The patients suffering form acute transmural myocardial infarction and treated with percutaneous transluminal coronary angioplasty will be included in the study. After the recanalisation of occluded artery, the reperfusion injury develops and the regeneration of ischemic tissue is impaired. The reactive oxygen species are partly responsible for reperfusion injury pathogenesis.Therapeutic area: Diseases [C] - Cardiovascular Diseases [C14]
- Registration Number
- EUCTR2012-004406-10-CZ
- Lead Sponsor
- niversity Hospital Hradec Kralove
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- 60
The patients, aged 50-75 years (postmenopausal women only), suffering from acute myocardial infarction, transmural, originating from large vessel damage, will be included in the study. There cannot be any previous myocardial infarction, any previous cardiosurgery or cardiogenic shock present (Kyllip 1-3).
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 30
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 30
Cardiogenic shock development, participation in another study, previus cardiosurgery, impossibility of primary PCI, diabetic decompensation, serious anamnestic nephropathy, serius anamnestic hepatopathy, cancer disease at present or previous five years, other serious comorbidities.
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method