Functional Correlates of Bipolar Disorders and Effects of the Psychoeducation. Assessment by Functional and Anatomic Neuroimaging.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 45
- 试验地点
- 2
- 主要终点
- fMRI measurement (neurophysiological [fMRI - activation and functional connectivity])
研究概览
简要总结
This research project follows two main objectives: 1) Assess anatomical and functional cerebral abnormalities in bipolar disorder. 2) Evaluate anatomical and functional changes after the application of a psychoeducational program in these patients. Specifically, this project aims to assess neurophysiological (fMRI - activation and functional connectivity) and neuroanatomical (morphometry and diffusion tensor imaging) specificities related to bipolar disorders and the therapeutic response to the psychoeducation. The results of this thesis project would also contribute to the validation of a pathophysiological model of the bipolar disorder.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •clinical diagnosis of bipolar disorders
- •euthymic (Montgomery and Asberg depression rating scale < 10, Young Mania rating scale < 10)
排除标准
- •other concomitant psychiatric disorders
研究组 & 干预措施
psychoeducation
psychoeducation (12 weeks)
干预措施: psychoeducation (Behavioral)
结局指标
主要结局
fMRI measurement (neurophysiological [fMRI - activation and functional connectivity])
时间窗: measurements were performed at T1 and T2 (up to 3 months)
measurements were performed before (T1) and after (T2) educational program of 12 sessions .One session last one hour and half once a week (they come at the hospital for all sessions : i.e. during 12 weeks). Thus, T1 to T2 is 3 months (average).
次要结局
未报告次要终点
研究者
AdministrateurDRC
Professor
University Hospital, Grenoble