Differentiating Unipolar and Bipolar Depression in Young Adults Using fMRI
Overview
- Phase
- Phase 4
- Intervention
- Selective Serotonin Reuptake Inhibitor (SSRI)
- Conditions
- Bipolar Disorder
- Sponsor
- The Cleveland Clinic
- Enrollment
- 192
- Locations
- 1
- Primary Endpoint
- HAM-D 17 Item: Hamilton Depression Rating Scale
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
The purpose of the study is to find out what parts of the brain have increased or decreased activity and connectivity in individuals who have bipolar disorder, major depression, or no history of mood disorder. Another purpose of this study is to use MRI images to determine which young adults with major depression may be at greater risk for developing mild or more severe symptoms of mania which suggests a diagnosis of bipolar disorder.
Detailed Description
The study involves two phases, phase one includes the screening visit and MRI. The second phase, for depression participants, involves in person follow ups for up to two years. The second phase, for healthy and bipolar participants, involves phone follow ups, every three months for up to two years. The purpose of this study is listed above. We plan to enroll 200 participants total.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Arms & Interventions
High Risk Depression
Interventions will include the prescribing of Selective serotonin reuptake inhibitor or Serotonin-norepinephrine reuptake inhibitor antidepressants, bupropion or other antidepressant.
Intervention: Selective Serotonin Reuptake Inhibitor (SSRI)
Low Risk Depression
Interventions will include the prescribing of Selective serotonin reuptake inhibitor or Serotonin-norepinephrine reuptake inhibitor antidepressants, bupropion or other antidepressant..
Intervention: Selective Serotonin Reuptake Inhibitor (SSRI)
Outcomes
Primary Outcomes
HAM-D 17 Item: Hamilton Depression Rating Scale
Time Frame: 24 months
Hamilton depression rating scale (17-item HAM-D): Scores can range from 0 to 52: No depression (0-7); Mild depression (8-16); Moderate depression (17-23); and Severe depression (≥24).
Secondary Outcomes
- YMRS: Young Mania Rating Scale(24 months)