Reduction of emergence reactions like cough, hypertension after general anaesthesia with intratracheal lignocaine as compared to intratracheal normal saline in endoscopic transsphenoidal pituitary surgery patients

Phase 1

• Conditions: Health Condition 1: null- Patients undergoing endoscopic trans sphenoidal pituitary surgery

• Registration Number: CTRI/2018/04/013011
• Lead Sponsor: All India Institute of Medical Sciences AIIMS New Delhi

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

1. Patients between 18 â?? 65 years of age.

2. ASA grade I & II patients.

3. Patients of Pituitary tumor posted for elective endoscopic transphenoidal surgery for tumor excision

Exclusion Criteria

1. Refusal of consent

2. Patients with history of smoking or chronic cough

3. Patients with history of upper respiratory tract infection (URI) in last 8 weeks

4. Patients with bleeding disorders

5. Previous laryngeal or tracheal surgery or pathology

6. Patients with history of gastric reflux

7. Patients with preoperative GCS <15

8. Patients with pulmonary disease, renal, cardiac or hepatic disorders, uncontrolled diabetes

9. Patients with clinical sign of hypothyroidism

10. Patients with BMI > 35kg/mt2

11. Patients with the history of hypertension (controlled or uncontrolled)

12. Patients with upper respiratory tract infection

13. Patients having history of allergic reactions to study drug

Post inclusion exclusion :

1. Need of more than 2 attempts of tracheal intubation or need of bougie for tracheal intubation

2. Patients who can not be extubated and are planned for elective ventilation

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To determine the effect of intratracheal lidocaine on suppressing the cough on emergence from general anesthesia in patients undergoing endoscopic transphenoidal pituitary surgery.Timepoint: During emergence from general anesthesia after the end of the surgery

Secondary Outcome Measures

Name	Time	Method
To determine effect of intratracheal lignocaine on HR and BP changes <br/ ><br>To determine the effect of intratracheal lignocaine on the emergence time, extubation time and recovery time <br/ ><br>To determine effect of intratracheal lignocaine on the neurological recovery in the early postoperative period. <br/ ><br>To determine effect of intratracheal lignocaine on arterial blood gas (ABG) in the early postoperative period <br/ ><br>Timepoint: During the maintenance phase and emergence phase of general anesthesia