Central pain sensitisation or (peri)articular damage: the origin of pain in SAPS A randomised, placebo controlled, blinded, cross-over trial

Withdrawn

Conditions: Chronische pijn in de schouder
Painful Arc Syndrome
Subacromial Impingement Syndrome
10013361

Registration Number: NL-OMON47590

Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Withdrawn

Sex: Not specified

Target Recruitment: 40

Inclusion Criteria

- Chronic shoulder pain (>3 months)
- Unilateral shoulder pain
- Suspicion of subacromial origin of pain (e.g. positive painful arc test, Hawkins-Kennedy test, empty can test)
- Presence of conventional ultrasonography
- Presence of conventional radiographs

Exclusion Criteria

- Younger than 18 years of age
- Tendinitis calcarea
- Full thickness rotator cuff tear
- Suspicion of capsulitis adhesiva after clinical examination
- Glenohumeral osteoarthritis
- Medication that potentially act on central pain sensitisation (e.g. pregabalin, amitriptylin, duloxetine)
- Use of opioid analgesics, e.g. oxycodone.
- Suspicion of symptomatic acromioclavicular osteoarthritis (e.g. positive cross body adduction test)
- History of fractures or dislocations of the shoulder
- Cardiac disease
- Comorbidities: neurological disorders (e.g. plexus lesion), rheumatic disorders (e.g. polymyalgia rheumatic), muscle dystrophies, metabolic disorders (e.g. hypothyreodism), neoplasms
- Diagnosed with other chronic pain syndrome, e.g. diabetic polyneuropathy, chronic low back pain or fibromyalgia
- Insufficient Dutch language skills
- No informed consent

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary study paramaters are: 1) the effect of subacromial injections on pain<br /><br>at rest and during abduction assessed with a visual analogue scale (VAS), 2)<br /><br>CPS assessed with bilateral Quantitative Sensory Testing (QST). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters (determinants) are two anchor questions for pain,<br /><br>assessment of succesful blinded allocation, shoulder muscle activation ratios<br /><br>(ARs), findings from ultrasonography, questionnaires and demographics and will<br /><br>be used to assess factors that are associated with pain in SAPS. </p><br>